p53 codon 72 polymorphism and breast cancer risk: A meta-analysis.
p53 codon 72 polymorphism and breast cancer risk: A meta-analysis.
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p53 密码子 72 多态性与乳腺癌风险：荟萃分析
DOI：
10.3892/etm.2013.1019
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发表时间：
2013-05
影响因子：
2.7
通讯作者：
Jia S
中科院分区：
文献类型：
--
作者：
Hou J;Jiang Y;Tang W;Jia S
p53基因是一种抑癌基因，在乳腺癌的发病中起重要作用。关于p53密码子72多态性（G>C）对乳腺癌风险的作用，研究产生了相互矛盾的结果;因此，进行荟萃分析，以估计p53密码子72多态性与乳腺癌之间的关联。对PubMed数据库进行筛选，以确定相关研究。选择包含p53密码子72多态性的可用基因型频率的研究，并使用合并的比值比（OR）和95%置信区间（CI）来评估相关性。61项已发表的研究，包括28，539名乳腺癌患者和32，788名对照。结果提示，不同基因型与乳腺癌的发生风险无关（Pro/Pro + Arg/Pro vs. Arg/Arg：OR=1.016，95% CI=0.931-1.11，P=0.722）。对称漏斗图、Egger检验（P=0.506）和Begg检验（P=0.921）均提示无发表偏倚。这项荟萃分析表明，p53密码子72 Pro/Pro + Arg/Pro基因型与乳腺癌风险增加无关。为了验证p53密码子72多态性与乳腺癌之间的关联，需要在全球范围内进行更多参与者的进一步研究。
p53 is a tumor suppressor gene and plays important roles in the etiology of breast cancer. Studies have produced conflicting results concerning the role of p53 codon 72 polymorphism (G>C) on the risk of breast cancer; therefore, a meta-analysis was performed to estimate the association between the p53 codon 72 polymorphism and breast cancer. Screening of the PubMed database was conducted to identify relevant studies. Studies containing available genotype frequencies of the p53 codon 72 polymorphism were selected and a pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. Sixty-one published studies, including 28,539 breast cancer patients and 32,788 controls were identified. The results suggest that variant genotypes are not associated with breast cancer risk (Pro/Pro + Arg/Pro vs. Arg/Arg: OR=1.016, 95% CI=0.931–1.11, P=0.722). The symmetric funnel plot, Egger’s test (P=0.506) and Begg’s test (P=0.921) were all suggestive of the lack of publication bias. This meta-analysis suggests that the p53 codon 72 Pro/Pro + Arg/Pro genotypes are not associated with an increased risk of breast cancer. To validate the association between the p53 codon 72 polymorphism and breast cancer, further studies with larger numbers of participants worldwide are required.
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影响因子：
5.3
作者：
HARRIS, N;BRILL, E;ROTTER, V
通讯作者：
ROTTER, V
影响因子：
30.8
作者：
Dumont, P;Leu, JIJ;Murphy, M
通讯作者：
Murphy, M
影响因子：
2.9
作者：
Alshatwi, Ali A.;Hasan, Tarique N.;Alsaif, Adulaziz A.
通讯作者：
Alsaif, Adulaziz A.
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
--
作者：
Damin, Andrea P. S.;Frazzon, Ana P. G.;Alexandre, Claudio O. P.
通讯作者：
Alexandre, Claudio O. P.