Long noncoding RNAs involvement in Epstein-Barr virus infection and tumorigenesis
Long noncoding RNAs involvement in Epstein-Barr virus infection and tumorigenesis
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长非编码RNA参与EB病毒感染和肿瘤发生
DOI：
10.1186/s12985-020-01308-y
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发表时间：
2020-04
期刊：
影响因子：
4.8
通讯作者：
Jianhong Lu
中科院分区：
文献类型：
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作者：
Jing Zhang;Xiaohan Li;Jingjin Hu;Pengfei Cao;Qijia Yan;Siwei Zhang;Wei Dang;Jianhong Lu
The Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus related to various types of cancers, including epithelial nasopharyngeal carcinoma, gastric carcinoma, and lymphoma. Long noncoding RNAs (lncRNAs) are expressed extensively in mammalian cells and play crucial roles in regulating various cellular processes and multiple cancers. Cellular lncRNAs can be differentially expressed induced by EBV infection. The dysregulated lncRNAs probably modulate the host immune response and other biological functions. At present, lncRNAs have been found to be significantly increased or decreased in EBV-infected cells, exosomes and EBV-associated cancers, suggesting their potential function and clinical application as biomarkers. In addition, EBV-encoded lncRNAs, BART and BHLF1 lncRNAs, may play roles in the viral oncogenesis. Analysis of the specific lncRNAs involved in interactions with the EBV machinery will provide information on their potential mechanism of action during multiple steps of EBV tumorigenesis. Here, we review the current knowledge regarding EBV-related lncRNAs and their possible roles in the pathogenesis of EBV-associated cancers.
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影响因子：
5.3
作者：
通讯作者：
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长非编码 RNA MALAT1 通过 miR155/树突状细胞特异性细胞间粘附分子 3 抓住非整联蛋白/IL10 轴诱导耐受性树突状细胞和调节性 T 细胞
影响因子：
7.3
作者：
Wu J;Zhang H;Zheng Y;Jin X;Liu M;Li S;Zhao Q;Liu X;Wang Y;Shi M;Zhang S;Tian J;Sun Y;Zhang M;Yu B
通讯作者：
Yu B
影响因子：
56.9
作者：
Carninci, P;Kasukawa, T;Hayashizaki, Y
通讯作者：
Hayashizaki, Y
影响因子：
6.1
作者：
Wang, Qing-Ming;Lian, Guang-Yu;Gong, Yi
通讯作者：
Gong, Yi
影响因子：
5
作者：
Shi, Linxi;Peng, Fang;Li, Ning
通讯作者：
Li, Ning