Regulation of the initiation of DNA replication in human cells.
Regulation of the initiation of DNA replication in human cells.
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DOI：
10.1016/j.dnarep.2018.09.003
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发表时间：
2018-12
期刊：
影响因子：
3.8
通讯作者：
Bakkenist CJ
中科院分区：
文献类型：
--
作者：
Moiseeva TN;Bakkenist CJ
如果没有高保真的DNA复制和复杂的基因组进化，物种的起源是不可能的，这些基因组的进化具有控制多个染色体上多个起始处的DNA复制的机制，使得基因组只复制一次。对酵母和非洲爪蛙卵提取液系统中控制复制解旋酶的组装和激活以及DNA复制启动的机制进行了鉴定和综述。这篇综述的目的是整理目前可用的关于控制人类细胞中DNA复制启动的机制的数据。DNA复制是化疗药物的靶点，因为癌细胞通常比大多数正常细胞增殖得更快，而且大多数癌细胞都获得了突变，使确保基因组稳定的机制失活。对启动DNA复制的机制的准确理解将允许合理设计针对DNA复制的新药物和组合的临床试验。目前，我们对启动DNA复制的机制的了解在很大程度上来自于在高度可驯化的酵母和非洲爪哇鸡蛋提取物系统中进行的实验。本综述的目的是总结目前已知的在人类细胞中启动DNA复制的情况。
The origin of species would not have been possible without high fidelity DNA replication and complex genomes evolved with mechanisms that control the initiation of DNA replication at multiple origins on multiple chromosomes such that the genome is duplicated once and only once. The mechanisms that control the assembly and activation of the replicative helicase and the initiation of DNA replication in yeast and Xenopus egg extract systems have been identified and reviewed. The goal of this review is to organize currently available data on the mechanisms that control the initiation of DNA replication in human cells. DNA replication is targeted by chemotherapeutic drugs as cancer cells generally proliferate faster than most normal cells, and most of them have acquired mutations that inactivate the mechanisms that ensure genome stability. A precise understanding of the mechanisms that initiate DNA replication will allow the rational design of clinical trials of new agents and combinations that target DNA replication. At this time our understanding of the mechanisms that initiate DNA replication is largely derived from experiments performed in highly tractable yeast and Xenopus egg extract systems. The objective of this review is to summarize what is currently known about the initiation of DNA replication in human cells.
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影响因子：
3.3
作者：
Bell SP;Labib K
通讯作者：
Labib K
DOI：
10.1155/2014/574850
发表时间：
2014
期刊：
Molecular biology international
影响因子：
--
作者：
Das M;Singh S;Pradhan S;Narayan G
通讯作者：
Narayan G
DOI：
10.1083/jcb.139.7.1597
发表时间：
1997-12-29
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ferreira J;Paolella G;Ramos C;Lamond AI
通讯作者：
Lamond AI
影响因子：
50.3
作者：
Dierov, J;Dierova, R;Carroll, M
通讯作者：
Carroll, M
影响因子：
56.9
作者：
Boos, Dominik;Yekezare, Mona;Diffley, John F. X.
通讯作者：
Diffley, John F. X.