Decreased Taurine and Creatine in the Thalamus May Relate to Behavioral Impairments in Ethanol-Fed Mice: A Pilot Study of Proton Magnetic Resonance Spectroscopy.
Decreased Taurine and Creatine in the Thalamus May Relate to Behavioral Impairments in Ethanol-Fed Mice: A Pilot Study of Proton Magnetic Resonance Spectroscopy.
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DOI：
10.1177/1536012117749051
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发表时间：
2018-01
影响因子：
2.8
通讯作者：
Cao Q
中科院分区：
文献类型：
--
作者：
Xu S;Zhu W;Wan Y;Wang J;Chen X;Pi L;Lobo MK;Ren B;Ying Z;Morris M;Cao Q
轻度肝性脑病(MHE)非常普遍，在高达80%的肝功能障碍患者中可观察到。轻度肝性脑病是指有认知障碍且无明显神经异常的肝性脑病。由于缺乏揭示大脑神经生化生物标志物变化所需的体内定量方法，临床治疗可能会被推迟。为了深入了解酒精性肝病所致神经功能障碍(NDF)的发生发展，采用晚期酒精性肝纤维化(LALF)小鼠模型，研究了丘脑和海马区与行为改变相关的神经化学水平的变化。用脑质子磁共振波谱和行为测试来确定LALF的神经化学改变及其与行为改变的关系。酒精处理组小鼠丘脑和海马区的谷氨酰胺水平均高于对照组。丘脑的牛磺酸和肌酸水平显著降低，并与酒精诱导的行为变化密切相关。慢性长期饮酒会导致晚期肝纤维化，核内神经化学变化，以及可能与NDF有关的行为变化。磁共振波谱是对大脑病理改变的一种敏感和非侵入性的测量，这可能为深入了解MHE的发生机制提供帮助。
Minimal hepatic encephalopathy (MHE) is highly prevalent, observed in up to 80% of patients with liver dysfunction. Minimal hepatic encephalopathy is defined as hepatic encephalopathy with cognitive deficits and no grossly evident neurologic abnormalities. Clinical management may be delayed due to the lack of in vivo quantitative methods needed to reveal changes in brain neurobiochemical biomarkers. To gain insight into the development of alcoholic liver disease–induced neurological dysfunction (NDF), a mouse model of late-stage alcoholic liver fibrosis (LALF) was used to investigate changes in neurochemical levels in the thalamus and hippocampus that relate to behavioral changes. Proton magnetic resonance spectroscopy of the brain and behavioral testing were performed to determine neurochemical alterations and their relationships to behavioral changes in LALF. Glutamine levels were higher in both the thalamus and hippocampus of alcohol-treated mice than in controls. Thalamic levels of taurine and creatine were significantly diminished and strongly correlated with alcohol-induced behavioral changes. Chronic long-term alcohol consumption gives rise to advanced liver fibrosis, neurochemical changes in the nuclei, and behavioral changes which may be linked to NDF. Magnetic resonance spectroscopy represents a sensitive and noninvasive measurement of pathological alterations in the brain, which may provide insight into the pathogenesis underlying the development of MHE.
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DOI：
10.1097/00000374-200006000-00015
发表时间：
2000-06-01
影响因子：
3.2
作者：
Batey, R;Cao, Q
通讯作者：
Cao, Q
DOI：
10.1016/s0006-291x(02)02672-4
发表时间：
2002-12-06
影响因子：
3.1
作者：
Cao, Q;Mak, KM;Lieber, CS
通讯作者：
Lieber, CS
DOI：
10.1016/s0006-291x(02)00586-7
发表时间：
2002-06-21
影响因子：
3.1
作者：
Cao, Q;Mak, KM;Lieber, CS
通讯作者：
Lieber, CS
影响因子：
1.9
作者：
Delis, Foteini;Thanos, Panayotis K.;Volkow, Nora D.
通讯作者：
Volkow, Nora D.
影响因子：
3.6
作者：
FERKO, AP
通讯作者：
FERKO, AP