Diffuse axonal injury after traumatic cerebral microbleeds: an evaluation of imaging techniques.

Diffuse axonal injury after traumatic cerebral microbleeds: an evaluation of imaging techniques.
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DOI:
10.4103/1673-5374.135330
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发表时间:
2014-06-15
影响因子:
6.1
通讯作者:
Tian Y
Tian Y
中科院分区:
医学2区
文献类型:
--
作者:
Liu J;Kou Z;Tian Y

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以往关于脑外伤的神经病理学研究主要集中在大结构的变化,例如脑挫裂伤、脑内血肿、硬膜外和硬膜下血肿后的临床预后。事实上,许多较小的伤害也可能导致严重的神经系统疾病。例如,脑微出血导致邻近神经元功能障碍以及皮质和皮质下结构之间的分离。这些微小的变化无法通过 CT 或传统 MRI 充分观察到。相比之下,基于梯度回波序列的磁敏感加权成像对血液代谢物和微出血非常敏感,可用于以高灵敏度和准确性评估创伤性脑微出血。脑微出血可被认为是弥漫性轴突损伤的重要影像学标志物,与预后具有潜在相关性。为此,本研究基于实验和临床研究,综述了显示创伤性脑微出血的影像学数据在评估脑神经元损伤和神经功能丧失中的作用。
Previous neuropathological studies regarding traumatic brain injury have primarily focused on changes in large structures, for example, the clinical prognosis after cerebral contusion, intracerebral hematoma, and epidural and subdural hematoma. In fact, many smaller injuries can also lead to severe neurological disorders. For example, cerebral microbleeds result in the dysfunction of adjacent neurons and the disassociation between cortex and subcortical structures. These tiny changes cannot be adequately visualized on CT or conventional MRI. In contrast, gradient echo sequence-based susceptibility-weighted imaging is very sensitive to blood metabolites and microbleeds, and can be used to evaluate traumatic cerebral microbleeds with high sensitivity and accuracy. Cerebral microbleed can be considered as an important imaging marker for diffuse axonal injury with potential relevance for prognosis. For this reason, based on experimental and clinical studies, this study reviews the role of imaging data showing traumatic cerebral microbleeds in the evaluation of cerebral neuronal injury and neurofunctional loss.
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