Chemical constituents and ACE inhibitory activity of desert plant Suaeda physophora Pall.
Chemical constituents and ACE inhibitory activity of desert plant Suaeda physophora Pall.
复制标题
沙漠植物碱蓬的化学成分及ACE抑制活性。
DOI：
10.1016/j.apsb.2013.07.003
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发表时间：
2013-09
影响因子：
14.5
通讯作者：
Xiaoguang Jia
中科院分区：
文献类型：
--
作者：
Ruizhi Men;Ning Li;Yachao Xing;Yingzhan Tang;Chengyu Tan;Fantong Meng;Juan Zhang;Hui Ni;Xiaoguang Jia
翅碱蓬是一种主要生长在新疆维吾尔自治区盐碱地的荒漠植物。为了更好地利用盐生植物，对新疆盐生植物中ACE抑制剂进行了筛选。结果表明，S. physophora具有显著的ACE抑制活性。因此，我们首先对其生化成分进行了研究。从紫茎泽兰地上部分分离得到一个新的喹唑啉类生物碱，命名为Suaedine（1），沿着得到6个已知化合物（2-7）。physophora通过一维和二维核磁共振、旋光和质谱分析确定了新喹唑啉生物碱的结构。黄酮类化合物（2-4）和酚类化合物（5）具有显著的ACE活性。首次对该植物的化学成分和生物活性进行了研究。
Suaeda physophoraPall. is a kind of desert plant mostly growing in saline habitats in Xinjiang Uygur Autonomous Region. In order to have a better utilization of halophytes, a screening for ACE inhibitors from halophytes growing in Xinjiang was carried out. The result showed that the 70% EtOH extract andn-BuOH extract ofS. physophoraPall. possessed significant ACE inhibitory activities. So we focused on its biochemical constituents firstly. One new quinazoline alkaloid, namely Suaedine (1), along with six known compounds (2–7) was isolated from the aerial parts ofS. physophoraPall. The structure of the new quinazoline alkaloid was established by one- and two-dimensional nuclear magnetic resonance, optical rotation and mass spectrometry analysis. The flavonoid compounds (2–4) and phenolic compound (5) exhibited significant ACE activities. It was the first time to focus on the chemical constituents and bioactivities of this plant.
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DOI：
10.1021/jo001273f
发表时间：
2001-01
期刊：
The Journal of organic chemistry
影响因子：
--
作者：
A. Katritzky;S. Mehta;Hai-ying He
通讯作者：
A. Katritzky;S. Mehta;Hai-ying He
DOI：
--
发表时间：
2008
期刊：
Journal of Shenyang Pharmaceutical University
影响因子：
--
作者：
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通讯作者：
Da-li Meng
影响因子：
5.8
作者：
LLOYD, AG;EMBERY, G;FOWLER, LJ
通讯作者：
FOWLER, LJ
DOI：
--
发表时间：
2008
期刊：
Guangdong Agricultural Sciences
影响因子：
--
作者：
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通讯作者：
Zhu Xiao-mei
DOI：
--
发表时间：
2007
期刊：
Journal of Shenyang Pharmaceutical University
影响因子：
--
作者：
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Wang Yong-qi