Portal hypertension correlates with splenic stiffness as measured with MR elastography.
Portal hypertension correlates with splenic stiffness as measured with MR elastography.
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DOI：
10.1002/jmri.22610
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发表时间：
2011-07
影响因子：
4.4
通讯作者：
Nyberg, Scott L.
中科院分区：
文献类型：
--
作者：
Nedredal, Geir I.;Yin, Meng;McKenzie, Travis;Lillegard, Joseph;Luebke-Wheeler, Jennifer;Talwalkar, Jayant;Ehman, Richard;Nyberg, Scott L.
在大型门静脉高压动物模型中，研究MRE评估的脾脏硬度与直接门静脉压力梯度（D-HVPG）测量值之间的相关性。通过胆总管结扎建立了胆汁淤积性肝病的成年犬。使用基于自旋回波的EPI MRE序列在基线、4周和8周时采集3-D/3轴腹部MRE数据。同时获得肝活检、血液样本和D-HVPG测量。4周后，动物发生门静脉高压（D-HVPG：11.0±5.1 mmHg），仅F1纤维化。8周后证实F3纤维化，尽管门静脉高压没有进一步升高（D-HVPG：11.3±3.2 mmHg）。从基线（1.72±0.33 kPa）到4周（3.54±0.31 kPa），脾脏的平均硬度增加了2倍以上，并在8周时稳定（3.38±0.06 kPa），其模式与门静脉压力的变化一致。脾脏硬度与D-HVPG呈正相关（r ~ 2 = 0.86，p<0.01）。这些发现表明在胆汁淤积性肝病的大型动物模型中门静脉高压症和肝纤维化的发展之间存在时间关系。观察到的脾脏硬度和D-HVPG之间的直接相关性表明，一种非侵入性的MRE方法来诊断和筛选门静脉高压症。
To investigate the correlation between MRE assessed spleen stiffness and direct portal vein pressure gradient (D-HVPG) measurements in a large animal model of portal hypertension. Cholestatic liver disease was established in adult canines by common bile duct ligation. A spin echo based EPI MRE sequence was used to acquire 3-D/3-axis abdominal MRE data at baseline, four weeks, and eight weeks. Liver biopsies, blood samples, and D-HVPG measurements were obtained simultaneously. Animals developed portal hypertension (D-HVPG: 11.0±5.1 mmHg) with only F1 fibrosis after four weeks. F3 fibrosis was confirmed after eight weeks despite no further rise in portal hypertension (D-HVPG: 11.3±3.2 mmHg). Mean stiffnesses of the spleen increased over two-fold from baseline (1.72±0.33 kPa) to four weeks (3.54±0.31 kPa), and stabilized at eight weeks (3.38±0.06 kPa) in a pattern consistent with changes in portal pressure. A positive correlation was observed between spleen stiffness and D-HVPG (r2 = 0.86, p<0.01). These findings indicate a temporal relationship between portal hypertension and the development of liver fibrosis in a large animal model of cholestatic liver disease. The observed direct correlation between spleen stiffness and D-HVPG suggest a non-invasive MRE approach to diagnose and screen for portal hypertension.
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影响因子：
29.4
作者：
Huwart, Laurent;Sempoux, Christine;Van Beers, Bernard E.
通讯作者：
Van Beers, Bernard E.
DOI：
10.2214/ajr.07.3504
发表时间：
2009-07
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
Talwalkar JA;Yin M;Venkatesh S;Rossman PJ;Grimm RC;Manduca A;Romano A;Kamath PS;Ehman RL
通讯作者：
Ehman RL
影响因子：
9.8
作者：
Turnes, J;Garcia-Pagan, JC;Bosch, J
通讯作者：
Bosch, J
影响因子：
1.9
作者：
Cardenas, Andres;Lowe, Robert;Afdhal, Nezam H.
通讯作者：
Afdhal, Nezam H.
影响因子：
13.5
作者：
Kim, WR;Brown, RS;El-Serag, H
通讯作者：
El-Serag, H