Early Atherosclerotic Inflammatory Pathways in Children with Obstructive Sleep Apnea.
Early Atherosclerotic Inflammatory Pathways in Children with Obstructive Sleep Apnea.
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DOI：
10.1016/j.jpeds.2021.08.031
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发表时间：
2021-12
影响因子：
5.1
通讯作者：
Amin, Raouf S.
中科院分区：
文献类型：
--
作者：
Smith, David F.;Schuler, Christine L.;Hossain, Md M.;Huang, Guixia;McConnell, Keith;Urbina, Elaine M.;Amin, Raouf S.
目的：评价阻塞性睡眠呼吸暂停(OSA)儿童和健康对照儿童颈动脉结构和功能的改变及炎症状态。研究对象为阻塞性睡眠呼吸暂停综合征患者和对照组(年龄5-13岁)。在下午6：00检测促炎细胞因子和急性期反应物用超声测定颈总动脉的测量值。验证性因子分析(CFA)用于确定细胞因子亚群及其对颈动脉测量的影响。96例患者(53例健康对照，43例阻塞性睡眠呼吸暂停综合征患者)。OSA与促炎细胞因子(CD40L、IL6和IL8)和高敏C反应蛋白(P<；ALL)增加有关。一个细胞因子亚组(IL-6和IL-8)与颈动脉功能指标呈负相关，表明动脉扩张性降低，僵硬增加(三种超声指标P<；0.05)，而肿瘤坏死因子-α对颈动脉功能的影响与该细胞因子亚组相反(P<；两种超声指标P<；0.05)。线性回归显示，肿瘤坏死因子-α与颈动脉功能的两项指标(每项指标均为0.05)之间存在显著相关性。与对照组相比，阻塞性睡眠呼吸暂停综合征儿童的颈动脉没有发生功能性或结构性改变。OSA与颈动脉结构和功能改变无直接关系，但与关键的促炎细胞因子(sCD40L、IL-6和IL-8)上调有关。IL-6和IL-8与颈动脉功能改变有关。需要进行纵向研究，以证明在我们人群中观察到的炎症环境是儿童动脉粥样硬化的先兆。
To evaluate structural and functional carotid changes and inflammatory profiles in children with OSA (obstructive sleep apnea) and healthy controls. Patients with OSA and matched controls (ages 5–13) were recruited. Pro-inflammatory cytokines and acute phase reactants were measured at 6:00 PM. Common carotid artery measures were determined using ultrasound. Confirmatory factor analysis (CFA) was used to determine subgroups of cytokines and their effects on carotid measures. Ninety-six patients participated (53 healthy controls, 43 patients with OSA). OSA was associated with increased pro-inflammatory cytokines (CD40L, IL6, and IL8) and high sensitivity C-reactive protein (P < .05 for all). One cytokine subgroup (IL-6 and IL-8) was negatively associated with markers of carotid function, indicating reduced arterial distensibility and increased stiffness (p<0.05 for three ultrasound measures); TNF-α had an opposing effect on carotid function compared with this cytokine subgroup (p<0.05 for two ultrasound measures). Linear regression demonstrated significant associations between TNF-α and two measures of carotid function (p<0.05 for each). Children with OSA did not have functional or structural carotid changes compared with controls. OSA was not directly associated with structural and functional carotid changes but was associated with upregulation of key pro-inflammatory cytokines (sCD40L, IL-6, and IL-8). Together, IL-6 and IL-8 were associated with changes in carotid function. Longitudinal studies are needed to demonstrate that the inflammatory milieu observed in our population is a precursor of atherosclerosis in children.
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影响因子：
4.9
作者：
Koren, D.;Chirinos, J. A.;Katz, L. E. L.;Mohler, E. R.;Gallagher, P. R.;Mitchell, G. F.;Marcus, C. L.
通讯作者：
Marcus, C. L.
影响因子：
4.3
作者：
Nadeem, Rashid;Molnar, Janos;Loomba, Rohit
通讯作者：
Loomba, Rohit
影响因子：
2.5
作者：
Martinez, Denis;Klein, Cristini;Goncalves Bos, Angelo Jose
通讯作者：
Goncalves Bos, Angelo Jose
DOI：
10.1016/0735-1097(94)00316-i
发表时间：
1995-01-01
影响因子：
24
作者：
ROMAN, MJ;PICKERING, TG;DEVEREUX, RB
通讯作者：
DEVEREUX, RB
影响因子：
9.6
作者：
Drager, Luciano F.;Polotsky, Vsevolod Y.;Lorenzi-Filho, Geraldo
通讯作者：
Lorenzi-Filho, Geraldo