Brief Report: Trends in Hospitalizations Due to Acute Coronary Syndromes and Stroke in Patients With Systemic Lupus Erythematosus, 1996 to 2012.
Brief Report: Trends in Hospitalizations Due to Acute Coronary Syndromes and Stroke in Patients With Systemic Lupus Erythematosus, 1996 to 2012.
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DOI：
10.1002/art.39758
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发表时间：
2016-11
影响因子：
13.3
通讯作者：
Ward, Michael M.
中科院分区：
文献类型：
--
作者：
Tektonidou, Maria G.;Wang, Zhong;Ward, Michael M.
心血管疾病（CVD）已被认为是系统性红斑狼疮（SLE）患者发病的主要原因，但目前尚不清楚，如果这些风险的认识提高已转化为CVD发病率在人群水平的改善。为了确定这一点，我们检查了1996年至2012年SLE患者因CVD事件住院率的全国趋势。我们使用全国住院患者样本来估计1996年至2012年SLE患者因急性心肌梗死、不稳定型心绞痛和缺血性卒中住院的比率。我们将这些趋势与普通人群进行了比较。在研究期间，估计有31，012例SLE患者因急性心肌梗死住院，4，160例因不稳定型心绞痛住院，26，144例因缺血性卒中住院。SLE患者因急性心肌梗死和缺血性卒中住院率随时间增加，而不稳定型心绞痛住院率下降。这些年来，一般人群中所有三种疾病的发生率都有所下降，一般人群中不稳定型心绞痛的住院率下降速度快于SLE患者。SLE患者对心血管疾病负担认识的提高尚未转化为急性心肌梗死或卒中住院率的降低。这可能是由于实施CVD风险因素修改的障碍，或尚未识别或有效针对SLE特定风险。
Cardiovascular disease (CVD) has been recognized as a major cause of morbidity in patients with systemic lupus erythematosus (SLE), but it is not clear if increased awareness of these risks has translated into improvements in CVD morbidity at the population level. To determine this, we examined national trends in rates of hospitalizations for CVD events in patients with SLE from 1996 to 2012. We used the Nationwide Inpatient Sample to estimate rates of hospitalizations for acute myocardial infarction, unstable angina, and ischemic stroke from 1996 to 2012 in patients with SLE. We compared these trends to those in the general population. During the study years, there were an estimated 31,012 hospitalizations for acute myocardial infarction, 4,160 hospitalizations for unstable angina, and 26,144 hospitalizations for ischemic stroke among patients with SLE. Rates of hospitalizations for acute myocardial infarction and ischemic stroke increased over time in patients with SLE, while rates for unstable angina decreased. Rates for all three conditions decreased in the general population over these years, with hospitalization rates for unstable angina decreasing faster in the general population than among patients with SLE. Increased awareness of the burden of CVD in patients with SLE has not yet translated into decreases in hospitalizations for acute myocardial infarction or stroke. This may be due to barriers in implementation of CVD risk factor modification, or SLE-specific risks that have not yet been identified or effectively targeted.
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影响因子：
120.7
作者：
Koton, Silvia;Schneider, Andrea L. C.;Coresh, Josef
通讯作者：
Coresh, Josef
影响因子：
2.6
作者：
Bengtsson, C.;Bengtsson, A. A.;Nived, O.
通讯作者：
Nived, O.
影响因子：
3.7
作者：
McCormick N;Lacaille D;Bhole V;Avina-Zubieta JA
通讯作者：
Avina-Zubieta JA
影响因子：
158.5
作者：
Boden, William E.;O'Rourke, Robert A.;Mathien, J.
通讯作者：
Mathien, J.
DOI：
10.3899/jrheum.130874
发表时间：
2014-04
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Bartels CM;Buhr KA;Goldberg JW;Bell CL;Visekruna M;Nekkanti S;Greenlee RT
通讯作者：
Greenlee RT