Aerosols
Aerosols
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气溶胶
作者：
L. Stitz;A. Aguzzi
我们和其他人最近报道了朊病毒可以通过气溶胶传播给老鼠。这些报告引发了公众对含朊病毒气溶胶可能构成的公共卫生威胁的热烈讨论。在此，我们就这些调查结果应置于何种背景下提出我们的看法。一方面，雾化的朊病毒可以传播疾病的事实不能被认为是朊病毒在自然情况下通过空气传播。另一方面，强调这样一个事实似乎很重要，即气溶胶很容易在各种各样的实验和自然环境条件下产生。气溶胶几乎是处理流体不可避免的后果；完全防止气溶胶的产生是非常困难的。虽然从未发现朊病毒在自然条件下可通过气溶胶传播，但只要可能出现潜在的朊病毒感染气溶胶，例如在处理脑物质、脑脊液和其他潜在污染材料的科学和诊断实验室以及屠宰场，就应努力尽量减少接触这种气溶胶。同样重要的是，朊病毒生物安全培训应侧重于控制和保护受朊病毒感染的气溶胶。
We and others have recently reported that prions can be transmitted to mice via aerosols. These reports spurred a lively public discussion on the possible public-health threats represented by prion-containing aerosols. Here we offer our view on the context in which these findings should be placed. On the one hand, the fact that nebulized prions can transmit disease cannot be taken to signify that prions are airborne under natural circumstances. On the other hand, it appears important to underscore the fact that aerosols can originate very easily in a broad variety of experimental and natural environmental conditions. Aerosols are a virtually unavoidable consequence of the handling of fluids; complete prevention of the generation of aerosols is very difficult. While prions have never been found to be transmissible via aerosols under natural conditions, it appears prudent to strive to minimize exposure to potentially prion-infected aerosols whenever the latter may arise – for example in scientific and diagnostic laboratories handling brain matter, cerebrospinal fluids, and other potentially contaminated materials, as well as abattoirs. Equally important is that prion biosafety training be focused on the control of, and protection from, prion-infected aerosols.
影响因子：
3.3
作者：
Agrawal, Anurag;Singh, Shashi Kant;Parikh, Indu
通讯作者：
Parikh, Indu