The contribution of maternal stress to preterm birth: issues and considerations.
The contribution of maternal stress to preterm birth: issues and considerations.
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DOI：
10.1016/j.clp.2011.06.007
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发表时间：
2011-09
影响因子：
2.1
通讯作者：
Lu MC
中科院分区：
文献类型：
--
作者：
Wadhwa PD;Entringer S;Buss C;Lu MC
早产是母婴健康方面最严重的问题。目前正在进行的研究，以阐明其根本原因和病理生理机制已确定产妇压力作为一个变量的利益。基于复杂常见疾病的因果关系的新兴模型，我们认为，母亲压力对早产风险的影响可能在很大程度上，作为上下文的函数而变化。在本文中，我们专注于选择关键问题和问题，强调需要更好地了解哪些特定的孕妇亚群，在什么情况下，在妊娠的哪个阶段，可能特别容易受到产妇压力的潜在有害影响。我们的讨论涉及的问题，产妇压力和候选人的生物（母体-胎盘-胎儿内分泌，免疫，血管和遗传）机制的表征和评估。我们建议采用更新的方法（生态瞬时评估）和生命过程的角度来进一步了解产妇压力对早产的贡献。
Preterm birth represents the most significant problem in maternal-child health. The ongoing search to elucidate its underlying causes and pathophysiological mechanisms has identified maternal stress as a variable of interest. Based on emerging models of causation of complex common disorders, we suggest that the effects of maternal stress on risk of preterm birth may, for the most part, vary as a function of context. In this paper we focus on select key issues and questions that highlight the need to develop a better understanding of which particular subgroups of pregnant women, under what circumstances, and at which stage(s) of gestation, may be especially vulnerable to the potentially detrimental effects of maternal stress. Our discussion addresses issues related to the characterization and assessment of maternal stress and candidate biological (maternal-placental-fetal endocrine, immune, vascular and genetic) mechanisms. We propose the adoption of newer approaches (ecological momentary assessment) and a life-course perspective to further our understanding of the contribution of maternal stress to preterm birth.
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