Hindered Diffusion of Oligosaccharides in High Strength Poly(ethylene glycol)/Poly(acrylic acid) Interpenetrating Network Hydrogels: Hydrodynamic Versus Obstruction Models.
Hindered Diffusion of Oligosaccharides in High Strength Poly(ethylene glycol)/Poly(acrylic acid) Interpenetrating Network Hydrogels: Hydrodynamic Versus Obstruction Models.
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DOI：
10.1016/j.polymer.2009.05.034
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发表时间：
2009-12-10
期刊：
影响因子：
4.6
通讯作者：
Frank, Curtis W.
中科院分区：
文献类型：
--
作者：
Waters, Dale J.;Frank, Curtis W.
采用凝胶平板扩散法测定了小分子低聚糖在聚乙二醇/聚丙烯酸互穿网络(PEGIPN)水凝胶中的扩散系数。检验了以前文献中提出的受阻扩散模型对实验数据的拟合能力。将仅基于流体力学影响的模型与仅基于溶质阻碍的模型进行了比较。为了考察聚合物体积分数对观察到的扩散系数的影响，通过改变水凝胶前驱体溶液中聚乙二醇酯的初始浓度从20到50wt./wt.%，系统地改变了聚合物在聚乙二醇胺互穿网络中的平衡体积分数。为了检验溶质半径对观察到的扩散系数的影响，通过测量葡萄糖(单糖)、麦芽糖(二糖)和麦芽三糖(三糖)的扩散系数，将溶质半径从3.3变化到5.1ó。流体力学模型和阻力模型都依赖于比例关系来预测扩散系数。基于对实验数据的拟合，对每个受阻扩散模型的适当标度关系进行了评估。所采用的比例关系对水动力模型的意义大于对障碍物模型的意义。无论采用何种标度关系，障碍模型都比流体力学模型更符合我们的实验数据。
Diffusion coefficients of small oligosaccharides within high strength poly(ethylene glycol)/poly(acrylic acid) interpenetrating network (PEG/PAA IPN) hydrogels were measured by diffusion through hydrogel slabs. The ability of hindered diffusion models previously presented in the literature to fit the experimental data is examined. A model based solely on effects due to hydrodynamics is compared to a model based solely on solute obstruction. To examine the effect of polymer volume fraction on the observed diffusion coefficients, the equilibrium volume fraction of polymer in PEG/PAA IPNs was systematically varied by changing the initial PEG polymer concentration in hydrogel precursor solutions from 20 to 50 wt./wt.%. To examine the effect of solute radius on the observed diffusion coefficients, solute radii were varied from 3.3 to 5.1 Å by measuring diffusion coefficients of glucose, a monosaccharide; maltose, a disaccharide; and maltotriose, a trisaccharide. Both the hydrodynamic and obstruction models rely on scaling relationships to predict diffusion coefficients. The proper scaling relationship for each of the hindered diffusion models is evaluated based on fits to experimental data. The scaling relationship employed is found to have a greater significance for the hydrodynamic model than the obstruction model. Regardless of the scaling relationship employed, the obstruction model provides a better fit to our experimental data than the hydrodynamic model.
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影响因子：
5.5
作者：
Cheng, Y;Prud'homme, RK;Thomas, JL
通讯作者：
Thomas, JL
DOI：
10.1016/0006-3002(63)91645-7
发表时间：
1963-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
LAURENT, TC;BJORK, I;PIETRUSZKIEWICZ, A
通讯作者：
PIETRUSZKIEWICZ, A
影响因子：
4.4
作者：
DEBYE, P;BUECHE, AM
通讯作者：
BUECHE, AM
影响因子：
2
作者：
Myung, David;Farooqui, Nabeel;Ta, Christopher N.
通讯作者：
Ta, Christopher N.
影响因子：
5.5
作者：
Amsden, B
通讯作者：
Amsden, B