Rebuttal to: The Benevolent Bile: Bile Acids as Stimulants of Liver Regeneration.
Rebuttal to: The Benevolent Bile: Bile Acids as Stimulants of Liver Regeneration.
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DOI：
10.1016/j.jcmgh.2022.02.002
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发表时间：
2022
影响因子：
7.2
通讯作者：
Anakk, S. A. Y. E. E. P. R. I. Y. A. D. A. R. S. H. I. N. I.
中科院分区：
文献类型：
--
作者：
Zhou, W. E. I. N. A. N.;Anakk, S. A. Y. E. E. P. R. I. Y. A. D. A. R. S. H. I. N. I.
Bhushan和Apte 1强调了胆汁酸(BAs)的有益作用，如增加BA水平可刺激肝部分切除(PH)或药物所致急性肝损伤后的再生和恢复。虽然我们同意BA在肝脏再生中的保护作用，但越来越多的证据表明，BA池的组成对下游信号转导至关重要。疏水性BA产生细胞毒性，而亲水性BA减轻肝脏损伤，池中BA的比例决定了疏水指数。缺失小的异二聚体伴侣2和富含石胆酸的饮食3都会增加疏水性BA池，导致胆汁梗死、胆管梗阻和肝脏损伤。此外，PH后BA的组成发生了变化，尤其是胆酸增加，鹅去氧胆酸减少，导致再生过程中BA池更亲水。从机制上讲，膜上的武田G蛋白偶联受体激活调节BA的组成，使其变得更亲水，从而防止细胞毒性BA的积累。4.
Bhushan and Apte 1 highlight the beneficial effects of bile acids (BAs), such that increasing BA levels stimulate regeneration and recovery after partial hepatectomy (PH) or drug-induced acute liver injury. Although we agree with the protective role of BAs in liver regeneration, increasing evidence points to the fact that the composition of the BA pool is crucial for downstream signaling.Hydrophobic BAs induce cytotoxicity while hydrophilic BAs alleviate liver injury, and the ratio of BAs in the pool determines the hydrophobic index. Deletion of small heterodimer partner 2 and a lithocholic acid–enriched diet 3 both can increase the hydrophobic BA pool, causing bile infarcts, bile duct obstruction, and liver injury. Moreover, altered BA composition after PH has been noted with a particular increase in cholic acid and a reduction in chenodeoxycholic acid, resulting in a more hydrophilic BA pool during regeneration. Mechanistically, the membrane Takeda G-protein–coupled receptor activation modulates BA composition to become more hydrophilic, and thus protects against cytotoxic BA accumulation. 4
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影响因子：
13.5
作者：
Jia, Xiaodong;Lu, Shanshan;Lu, Yinying
通讯作者：
Lu, Yinying
影响因子：
6
作者：
Fickert, P;Fuchsbichler, A;Trauner, M
通讯作者：
Trauner, M
DOI：
10.1016/j.jcmgh.2022.02.001
发表时间：
2022
影响因子：
7.2
作者：
Bhushan, Bharat;Apte, Udayan
通讯作者：
Apte, Udayan
DOI：
10.1016/j.jhepr.2020.100214
发表时间：
2021-04
期刊：
JHEP reports : innovation in hepatology
影响因子：
--
作者：
Bidault-Jourdainne V;Merlen G;Glénisson M;Doignon I;Garcin I;Péan N;Boisgard R;Ursic-Bedoya J;Serino M;Ullmer C;Humbert L;Abdelrafee A;Golse N;Vibert E;Duclos-Vallée JC;Rainteau D;Tordjmann T
通讯作者：
Tordjmann T
影响因子：
9
作者：
Evangelakos I;Heeren J;Verkade E;Kuipers F
通讯作者：
Kuipers F