Cellular and acellular pertussis vaccines in adults.

Cellular and acellular pertussis vaccines in adults.
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成人细胞和非细胞百日咳疫苗。

DOI:
10.1086/515064
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发表时间:
1999
期刊:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子:
--
通讯作者:
W. Keitel
W. Keitel
中科院分区:
--
文献类型:
--
作者:
W. Keitel

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以前认为儿童期后接种百日咳疫苗是不必要的,因为老年人很少出现严重疾病和并发症。老年青少年和成人中百日咳发病率的上升以及感染从成人向婴儿的传播表明,可能需要加强免疫,以更有效地控制所有年龄段的百日咳。全细胞百日咳疫苗被认为不适合成人常规使用,因为有报道称注射部位经常出现中度至重度反应原性,并且偶尔会出现全身反应。安全有效的无细胞百日咳疫苗的推出为我们提供了重新考虑青少年和成人加强免疫的机会。几种含有百日咳博德特氏菌纯化成分的疫苗在给予健康成年人时具有良好的耐受性和高免疫原性。清楚了解百日咳对青少年和成人的影响将有助于确定儿童期后加强免疫的必要性。
Immunization against pertussis after childhood previously was considered unnecessary, because severe illness and complications rarely developed in older persons. The rising incidence of pertussis among older adolescents and adults and the transmission of infection from adults to infants suggest that booster immunization may be necessary to more effectively control pertussis in all age groups. Whole cell pertussis vaccines are regarded as unsuitable for routine use in adults because of reports of frequent moderate to severe reactogenicity at the injection site and occasional systemic reactions. The introduction of safe and effective acellular pertussis vaccines provides us with an opportunity to reconsider booster immunization of adolescents and adults. Several vaccines containing purified component(s) of Bordetella pertussis have been well tolerated and highly immunogenic when given to healthy adults. A clear understanding of the impact of pertussis in adolescents and adults will help to define the need for booster immunization after childhood.
灭活脊髓灰质炎病毒疫苗与白喉-百日咳-破伤风疫苗联合使用时对百日咳博德特氏菌抗原抗体反应的影响。
DOI: 10.1093/clinids/22.1.59
发表时间: 1996
期刊: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子: --
作者:
Halperin,SA;Langley,JM;Eastwood,BJ
通讯作者: Eastwood,BJ
青少年和成人百日咳:是时候重新免疫了?
DOI: --
发表时间: 1995
期刊: Seminars in respiratory infections
影响因子: --
作者:
Keitel,WA;Edwards,KM
通讯作者: Edwards,KM
健康成人无细胞百日咳疫苗的随机临床试验:5 种疫苗的剂量反应比较及其对加强免疫的影响。
DOI: 10.1086/314869
发表时间: 1999
期刊: The Journal of infectious diseases
影响因子: --
作者:
Keitel,WA;Muenz,LR;Decker,MD;Englund,JA;Mink,CM;Blumberg,DA;Edwards,KM
通讯作者: Edwards,KM