Effect of inactivated poliovirus vaccine on the antibody response to Bordetella pertussis antigens when combined with diphtheria-pertussis-tetanus vaccine.
Effect of inactivated poliovirus vaccine on the antibody response to Bordetella pertussis antigens when combined with diphtheria-pertussis-tetanus vaccine.
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灭活脊髓灰质炎病毒疫苗与白喉-百日咳-破伤风疫苗联合使用时对百日咳博德特氏菌抗原抗体反应的影响。
DOI：
10.1093/clinids/22.1.59
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Eastwood,BJ
中科院分区：
文献类型：
--
作者：
Halperin,SA;Langley,JM;Eastwood,BJ
为了确定白喉、破伤风类毒素和全细胞百日咳疫苗联合灭活脊髓灰质炎病毒疫苗是否会干扰百日咳疫苗的免疫原性，我们对2、4和6个月龄免疫的婴儿进行了一项随机试验，即白喉、破伤风类毒素和百日咳疫苗联合灭活脊髓灰质炎病毒疫苗作为单次注射或作为两次单独注射在同一次访问中。共有84名婴儿参加了这项研究；44例单次注射，40例分次注射。免疫前，两组间抗体值无差异。两剂疫苗接种后，单次注射免疫的婴儿丝状血凝素抗体（8.3 vs. 23.7 ELISA单位，P< 0.001）、菌毛抗体（266.5 vs. 771.8 ELISA单位，P< 0.01）和69kD膜蛋白抗体（442.2 vs. 1352 ELISA单位，P< 0.001）均显著降低。在第三次给药后，这些差异仍然存在，百日咳毒素抗体（10.0比35.5 ELISA单位，P< 0.001）和全细菌抗原制备（2667比3829 ELISA单位，P< 0.05）也检测到差异。我们得出结论，当灭活脊髓灰质炎病毒疫苗与白喉、破伤风类毒素和百日咳疫苗联合使用时，抗体对百日咳疫苗的反应减弱。
To determine if inactivated poliovirus vaccine combined with diphtheria and tetanus toxoids and whole-cell pertussis vaccine interferes with the immunogenicity of pertussis vaccine, we performed a randomized trial of diphtheria and tetanus toxoids and pertussis vaccine combined with inactivated poliovirus vaccine given as a single injection or as two separate injections at the same visit to infants immunized at 2, 4, and 6 months of age. A total of 84 infants were enrolled in the study; 44 received the single injection, and 40 received separate injections. Before immunization, there were no differences in antibody values between the two groups. After two vaccine doses, infants immunized with the single injection had significantly lower values of antibody to filamentous hemagglutinin (8.3 vs. 23.7 ELISA units;P< .001), fimbriae (266.5 vs. 771.8 ELISA units;P< 0.01), and the 69kD membrane protein (442.2 vs. 1,352ELISA units; P < .001). After the third dose, these differences persisted, and differences were also detected for antibody to pertussis toxin (10.0 vs. 35.5 ELISA units;P< .001) and a whole-bacteria antigen preparation (2,667 vs. 3,829 ELISA units;P< .05). We conclude that there is a diminished antibody response to the pertussis vaccine when inactivated poliovirus vaccine is combined with the diphtheria and tetanus toxoids and pertussis vaccine.
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婴儿针对脊髓灰质炎、白喉、百日咳和破伤风的多重抗原免疫
影响因子：
8
作者：
C. D. Barrett;I. McLean;J. Molner;E. A. Timm;C. Weiss
通讯作者：
C. Weiss
全细胞百日咳疫苗接种和百日咳博德特氏菌感染后百日咳凝集素的同种型和抗原特异性
影响因子：
3.1
作者：
C. Mink;C. H. O'Brien;S. Wassilak;A. Deforest;B. Meade
通讯作者：
B. Meade
DOI：
10.1001/jama.1933.02740280007003
发表时间：
1933-07-01
影响因子：
--
作者：
Madsen, T
通讯作者：
Madsen, T
DOI：
10.1111/j.1651-2227.1980.tb07056.x
发表时间：
1980-01-01
期刊：
ACTA PAEDIATRICA SCANDINAVICA
影响因子：
--
作者：
RUUSKANEN, O;VILJANEN, MK;PELTONEN, T
通讯作者：
PELTONEN, T
四联抗原中的脊髓灰质炎成分：儿童增强反应的对照临床研究
DOI：
10.1001/jama.1960.03030090022005
发表时间：
1960
期刊：
JAMA
影响因子：
--
作者：
D. Bordt;J. W. Whalen;P. A. Boyer;A. R. Pursell;Francis P. Staffieri
通讯作者：
Francis P. Staffieri