Advanced Materials for SARS-CoV-2 Vaccines.
Advanced Materials for SARS-CoV-2 Vaccines.
复制标题
SARS-CoV-2 疫苗的先进材料。
DOI：
10.1002/adma.202107781
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Lovell JF
中科院分区：
文献类型：
--
作者：
Mabrouk MT;Huang WC;Martinez-Sobrido L;Lovell JF
由严重急性呼吸道冠状病毒 2 (SARS-CoV-2) 引起的 2019 年冠状病毒病 (COVID-19) 大流行已导致全球数百万人死亡，疫苗也成为人们关注的焦点，成为缓解疫情的首选方法。尽管许多发展中国家仍未接种疫苗，但病毒学、基因组学、结构生物学和疫苗技术的进步使得 COVID-19 疫苗得以快速、前所未有的推广。已经开发或部署了几种针对 SARS-CoV-2 的新疫苗平台，其中大多数针对大型病毒刺突免疫原。那些能够以低剂量安全诱导强而持久的抗体反应的抗体是有利的，并且那些能够快速大规模生产的抗体也是有利的。几乎所有 COVID-19 疫苗和佐剂都具有纳米级或微米级尺寸，代表多样化且独特的生物材料。病毒载体疫苗平台、脂质纳米颗粒mRNA疫苗和亚单位疫苗的多聚体展示技术备受关注。纳米级疫苗佐剂也已与其他疫苗联合使用。为了应对当前的大流行，并为未来可能出现的大流行做好准备，在不久的将来将继续开发先进的疫苗技术。本文总结了最近用于开发 COVID-19 疫苗的先进材料的使用情况。疫苗一直是全球应对 SARS-CoV-2 的主要焦点。先进材料在实现当前已部署的有效疫苗方面发挥了作用，并且在为应对大流行而开发的下一代疫苗中也显示出了前景。
The ongoing coronavirus disease 2019 (COVID‐19) pandemic, caused by severe acute respiratory coronavirus 2 (SARS‐CoV‐2), has killed untold millions worldwide and has hurtled vaccines into the spotlight as a go‐to approach to mitigate it. Advances in virology, genomics, structural biology, and vaccine technologies have enabled a rapid and unprecedented rollout of COVID‐19 vaccines, although much of the developing world remains unvaccinated. Several new vaccine platforms have been developed or deployed against SARS‐CoV‐2, with most targeting the large viral Spike immunogen. Those that safely induce strong and durable antibody responses at low dosages are advantageous, as well are those that can be rapidly produced at a large scale. Virtually all COVID‐19 vaccines and adjuvants possess nanoscale or microscale dimensions and represent diverse and unique biomaterials. Viral vector vaccine platforms, lipid nanoparticle mRNA vaccines and multimeric display technologies for subunit vaccines have received much attention. Nanoscale vaccine adjuvants have also been used in combination with other vaccines. To deal with the ongoing pandemic, and to be ready for potential future ones, advanced vaccine technologies will continue to be developed in the near future. Herein, the recent use of advanced materials used for developing COVID‐19 vaccines is summarized. Vaccines have been a major focus of the global SARS‐CoV‐2 response. Advanced materials have played a role in enabling the current generation of effective vaccines that have been deployed, and also they have shown promise in next‐generation vaccines that are being developed in response to the pandemic.
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影响因子：
9.2
作者：
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通讯作者：
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