Antimicrobial Peptides: Novel Source and Biological Function With a Special Focus on Entomopathogenic Nematode/Bacterium Symbiotic Complex.
Antimicrobial Peptides: Novel Source and Biological Function With a Special Focus on Entomopathogenic Nematode/Bacterium Symbiotic Complex.
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DOI：
10.3389/fmicb.2021.555022
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发表时间：
2021
影响因子：
5.2
通讯作者：
Jin F
中科院分区：
文献类型：
--
作者：
De Mandal S;Panda AK;Murugan C;Xu X;Senthil Kumar N;Jin F
多重耐药微生物的迅速出现已成为对公共卫生的最严重威胁之一。可用抗生素的有效性下降导致感染控制失败，导致死亡风险很高。在几种替代品中，抗菌肽（AMP）可作为抗生素的潜在替代品，以解决多重耐药病原体的出现和传播。这些小蛋白质具有强效的抗菌活性，也是免疫系统的重要组成部分。虽然已经报道和表征了几种AMP，但与其潜在的医学应用相关的研究有限。本文综述了具有高抗菌活性的抗菌肽的新来源，包括昆虫病原线虫/细菌（EPN/EPB）共生复合体。此外，来源于昆虫、线虫和海洋生物的AMP以及可以补充治疗性肽的缺陷的拟肽抗微生物剂的设计已被用作模板。
The rapid emergence of multidrug resistant microorganisms has become one of the most critical threats to public health. A decrease in the effectiveness of available antibiotics has led to the failure of infection control, resulting in a high risk of death. Among several alternatives, antimicrobial peptides (AMPs) serve as potential alternatives to antibiotics to resolve the emergence and spread of multidrug-resistant pathogens. These small proteins exhibit potent antimicrobial activity and are also an essential component of the immune system. Although several AMPs have been reported and characterized, studies associated with their potential medical applications are limited. This review highlights the novel sources of AMPs with high antimicrobial activities, including the entomopathogenic nematode/bacterium (EPN/EPB) symbiotic complex. Additionally, the AMPs derived from insects, nematodes, and marine organisms and the design of peptidomimetic antimicrobial agents that can complement the defects of therapeutic peptides have been used as a template.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1007/s10989-018-9789-3
发表时间：
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