Phase-locking of resting-state brain networks with the gastric basal electrical rhythm.
Phase-locking of resting-state brain networks with the gastric basal electrical rhythm.
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DOI：
10.1371/journal.pone.0244756
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Pekar JJ
中科院分区：
文献类型：
--
作者：
Choe AS;Tang B;Smith KR;Honari H;Lindquist MA;Caffo BS;Pekar JJ
胃体中的Cajal肌间质细胞网络充当其“起搏器”，持续产生约0.05 Hz的电慢波，其主要通过迷走神经传入传递到大脑。最近的一项研究将静息态功能性MRI（rsfMRI）与同步表面胃电描记术（EGG）结合起来，将皮肤电极放置在上腹部，发现12个大脑区域的活动与胃基础电节律显著锁相。因此，我们询问使用空间独立成分分析（伊卡）方法估计的大脑静息状态网络（RSN）的波动是否可能与胃同步。在本研究中，为了确定任何RSN是否与胃节律锁相，个体参与者进行了22次扫描;在每次扫描中，采集了两次15分钟的同步EGG和rsfMRI数据。三次会议的EGG数据有微弱的胃信号，被排除在外;其他19次会议产生了总共9.5小时的数据。使用伊卡组分析rsfMRI数据;估计RSN时程;对于每次运行，计算每个RSN和胃信号之间的锁相值（PLV）。为了评估统计学显著性，将所有“不匹配”数据对（在不同日期采集的EGG和rsfMRI数据）的PLV用作替代数据，以生成每个RSN的零分布。在总共18个RSN中，发现三个与基础胃节律显著锁相，即小脑网络、背侧体感-运动网络和默认模式网络。肠-脑轴（维持中枢神经系统和内脏之间的内感受性反馈）的中断被认为与各种疾病有关;脑rsfMRI数据中胃的亚慢节律的表现可能对临床人群的研究有用。
A network of myenteric interstitial cells of Cajal in the corpus of the stomach serves as its “pacemaker”, continuously generating a ca 0.05 Hz electrical slow wave, which is transmitted to the brain chiefly by vagal afferents. A recent study combining resting-state functional MRI (rsfMRI) with concurrent surface electrogastrography (EGG), with cutaneous electrodes placed on the epigastrium, found 12 brain regions with activity that was significantly phase-locked with this gastric basal electrical rhythm. Therefore, we asked whether fluctuations in brain resting state networks (RSNs), estimated using a spatial independent component analysis (ICA) approach, might be synchronized with the stomach. In the present study, in order to determine whether any RSNs are phase-locked with the gastric rhythm, an individual participant underwent 22 scanning sessions; in each, two 15-minute runs of concurrent EGG and rsfMRI data were acquired. EGG data from three sessions had weak gastric signals and were excluded; the other 19 sessions yielded a total of 9.5 hours of data. The rsfMRI data were analyzed using group ICA; RSN time courses were estimated; for each run, the phase-locking value (PLV) was computed between each RSN and the gastric signal. To assess statistical significance, PLVs from all pairs of “mismatched” data (EGG and rsfMRI data acquired on different days) were used as surrogate data to generate a null distribution for each RSN. Of a total of 18 RSNs, three were found to be significantly phase-locked with the basal gastric rhythm, namely, a cerebellar network, a dorsal somatosensory-motor network, and a default mode network. Disruptions to the gut-brain axis, which sustains interoceptive feedback between the central nervous system and the viscera, are thought to be involved in various disorders; manifestation of the infra-slow rhythm of the stomach in brain rsfMRI data could be useful for studies in clinical populations.
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影响因子：
11
作者：
Di Martino, A.;Yan, C-G;Li, Q.;Denio, E.;Castellanos, F. X.;Alaerts, K.;Anderson, J. S.;Assaf, M.;Bookheimer, S. Y.;Dapretto, M.;Deen, B.;Delmonte, S.;Dinstein, I.;Ertl-Wagner, B.;Fair, D. A.;Gallagher, L.;Kennedy, D. P.;Keown, C. L.;Keysers, C.;Lainhart, J. E.;Lord, C.;Luna, B.;Menon, V.;Minshew, N. J.;Monk, C. S.;Mueller, S.;Mueller, R. A.;Nebel, M. B.;Nigg, J. T.;O'Hearn, K.;Pelphrey, K. A.;Peltier, S. J.;Rudie, J. D.;Sunaert, S.;Thioux, M.;Tyszka, J. M.;Uddin, L. Q.;Verhoeven, J. S.;Wenderoth, N.;Wiggins, J. L.;Mostofsky, S. H.;Milham, M. P.
通讯作者：
Milham, M. P.
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
--
作者：
BOZLER, E
通讯作者：
BOZLER, E
每周休息状态fMRI的可重复性和时间结构在3。5年内。
影响因子：
3.7
作者：
Choe AS;Jones CK;Joel SE;Muschelli J;Belegu V;Caffo BS;Lindquist MA;van Zijl PC;Pekar JJ
通讯作者：
Pekar JJ
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y