Chronic chemogenetic manipulation of ventral pallidum targeted neurons in male rats fed an obesogenic diet.
Chronic chemogenetic manipulation of ventral pallidum targeted neurons in male rats fed an obesogenic diet.
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DOI：
10.1016/j.brainres.2022.147886
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发表时间：
2022-06-01
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
目前的肥胖治疗方法并不能长期可靠地减轻体重。新的介入策略，包括化学遗传学，基于临床前动物研究带来了希望。在这里，我们关注腹侧苍白球（VP），因为它在饮食行为中起着明确的作用。慢性抑制性或兴奋性化学发生激活被用来调节肥胖饮食大鼠的vp靶向神经元的活动。基于对急性VP操作的研究，我们假设VP抑制会减少体重增加，而VP刺激会增加体重。相反，随着时间的推移，这两种方法都会导致体重增加，而且与摄入水平没有明显的联系。我们推测腹侧纹状体结构和代谢中心之间复杂的相互反馈可能是我们意外发现的基础。无论如何，这项研究表明，通过慢性神经调节预防肥胖的策略的结果可能很难从先前使用急性干预的临床前研究中预测出来。
Current treatments for obesity do not reliably reduce body weight over time. New interventional strategies, including chemogenetics, carry promise based on preclinical animal studies. Here, we focused on the ventral pallidum (VP) due to its clearly established role in eating behavior. Chronic inhibitory or excitatory chemogenetic activation was used to modulate the activity of VP-targeted neurons in rats on an obesogenic diet. Based on studies using acute VP manipulations, we hypothesized that VP inhibition would decrease weight gain, while VP stimulation would increase weight. Instead, both manipulations caused weight gain over time, and in a manner not clearly linked to consumption levels. We theorize that the complex reciprocal feedback between ventral striatal structures and metabolic centers likely underpin our unexpected findings. Regardless, this study suggests that the result of strategies to prevent obesity with chronic neuromodulation could be difficult to predict from prior preclinical studies that have used acute interventions.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
16.2
作者：
Creed M;Ntamati NR;Chandra R;Lobo MK;Lüscher C
通讯作者：
Lüscher C
影响因子：
16.6
作者：
Faget L;Zell V;Souter E;McPherson A;Ressler R;Gutierrez-Reed N;Yoo JH;Dulcis D;Hnasko TS
通讯作者：
Hnasko TS
影响因子：
9
作者：
Christou, Nicolas V.;Look, Didier;MacLean, Lloyd D.
通讯作者：
MacLean, Lloyd D.
影响因子：
6.1
作者：
Choi, SuJean;DiSilvio, Briana;Fernstrom, John D.
通讯作者：
Fernstrom, John D.