Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum.
Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum.
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DOI：
10.1038/s41467-018-03125-y
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发表时间：
2018-02-27
影响因子：
16.6
通讯作者：
Hnasko TS
中科院分区：
文献类型：
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作者：
Faget L;Zell V;Souter E;McPherson A;Ressler R;Gutierrez-Reed N;Yoo JH;Dulcis D;Hnasko TS
腹侧苍白球(VP)位于感觉、运动和认知加工之间的交界处，在提高对奖励的行为反应方面具有特殊的作用。虽然VP主要是GABA能的，但最近发现了谷氨酸神经元，尽管它们的相对丰度和各自的作用尚不清楚。在这里，我们发现VP-谷氨酸神经元集中在吻侧腹内侧VP，并投射到与VP-GABA神经元性质相似的靶点。在功能水平上，我们利用光遗传学证明，VP-GABA神经元中的活动可以驱动阳性强化，特别是通过投射到腹侧被盖区(VTA)。另一方面，激活VP谷氨酸神经元导致行为回避，特别是通过投射到外侧缰核。这些发现突显了VP神经元在行为强化中的细胞类型和投射靶点的特定作用，其调节失调可能导致与药物成瘾和其他神经精神疾病相关的阴性症状的出现。腹侧钯(VP)参与奖赏，主要含有GABA能神经元，但也含有谷氨酸能神经元。在这里，作者描述了谷氨酸能VP神经元的特征，并表明谷氨酸能和GABA能投射分别在回避和加强中发挥作用。
The ventral pallidum (VP) lies at the interface between sensory, motor, and cognitive processing—with a particular role in mounting behavioral responses to rewards. Though the VP is predominantly GABAergic, glutamate neurons were recently identified, though their relative abundances and respective roles are unknown. Here, we show that VP glutamate neurons are concentrated in the rostral ventromedial VP and project to qualitatively similar targets as do VP GABA neurons. At the functional level, we used optogenetics to show that activity in VP GABA neurons can drive positive reinforcement, particularly through projections to the ventral tegmental area (VTA). On the other hand, activation of VP glutamate neurons leads to behavioral avoidance, particularly through projections to the lateral habenula. These findings highlight cell-type and projection-target specific roles for VP neurons in behavioral reinforcement, dysregulation of which could contribute to the emergence of negative symptoms associated with drug addiction and other neuropsychiatric disease. The ventral palladium (VP) is involved in reward and contains mostly GABAergic neurons, but also glutamatergic neurons. Here, the authors characterize glutamatergic VP neurons and show that glutamatergic versus GABAergic projections play roles in avoidance and reinforcement, respectively.
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影响因子：
8.8
作者：
Faget L;Osakada F;Duan J;Ressler R;Johnson AB;Proudfoot JA;Yoo JH;Callaway EM;Hnasko TS
通讯作者：
Hnasko TS
影响因子：
4.7
作者：
JOHNSON, PI;STELLAR, JR;PAUL, AD
通讯作者：
PAUL, AD
影响因子：
16.2
作者：
Hnasko, Thomas S.;Chuhma, Nao;Zhang, Hui;Goh, Germaine Y.;Sulzer, David;Palmiter, Richard D.;Rayport, Stephen;Edwards, Robert H.
通讯作者：
Edwards, Robert H.
影响因子：
64.8
作者：
Golden SA;Heshmati M;Flanigan M;Christoffel DJ;Guise K;Pfau ML;Aleyasin H;Menard C;Zhang H;Hodes GE;Bregman D;Khibnik L;Tai J;Rebusi N;Krawitz B;Chaudhury D;Walsh JJ;Han MH;Shapiro ML;Russo SJ
通讯作者：
Russo SJ
影响因子：
64.8
作者：
通讯作者：
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