Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment.
Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment.
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DOI：
10.3390/ijms19082299
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发表时间：
2018-08-05
影响因子：
5.6
通讯作者：
Tweardy DJ
中科院分区：
文献类型：
--
作者：
Kasembeli MM;Bharadwaj U;Robinson P;Tweardy DJ
信号转导和转录激活因子（STAT） 3在宿主对损伤的反应中起核心作用。它在细胞内被许多细胞因子迅速激活，尤其是IL-6家族中的细胞因子，导致促增殖和促生存程序，帮助宿主恢复体内平衡。然而，随着持续激活，慢性炎症和纤维化随之而来，导致许多使人衰弱的疾病。这篇综述总结了我们对STAT3的作用及其在慢性炎症和/或纤维化疾病中的靶向作用的理解进展，重点是那些最大的未满足医疗需求的疾病。
Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeostasis. With persistent activation, however, chronic inflammation and fibrosis ensue, leading to a number of debilitating diseases. This review summarizes advances in our understanding of the role of STAT3 and its targeting in diseases marked by chronic inflammation and/or fibrosis with a focus on those with the largest unmet medical need.
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影响因子：
7.3
作者：
Babaei, Rohollah;Schuster, Maximilian;Vegiopoulos, Alexandros
通讯作者：
Vegiopoulos, Alexandros
影响因子：
158.5
作者：
Bel, Elisabeth H.;Wenzel, Sally E.;Pavord, Ian D.
通讯作者：
Pavord, Ian D.
影响因子：
30.8
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通讯作者：
Rioux, John D.
影响因子：
3.7
作者：
Caiello I;Minnone G;Holzinger D;Vogl T;Prencipe G;Manzo A;De Benedetti F;Strippoli R
通讯作者：
Strippoli R
影响因子：
5.2
作者：
Carpenter RL;Lo HW
通讯作者：
Lo HW