Bone marrow adipose tissue is associated with fracture history in anorexia nervosa.
Bone marrow adipose tissue is associated with fracture history in anorexia nervosa.
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DOI：
10.1007/s00198-022-06527-3
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发表时间：
2022-12
影响因子：
4
通讯作者：
Fazeli, P. K.
中科院分区：
文献类型：
--
作者：
Dang, T.;Faje, A. T.;Meenaghan, E.;Bredella, M. A.;Bouxsein, M. L.;Klibanski, A.;Fazeli, P. K.
神经性厌食症（AN）是一种以低体重、低骨密度和骨折风险增加为特征的精神疾病。尽管骨密度降低，骨折风险升高，但DXA评估的骨密度并不能区分AN患者既往有骨折史的个体与无骨折史的个体。尽管外周脂肪组织储存减少，但AN患者的骨髓脂肪组织（BMAT）增加，这与BMD呈负相关。BMAT增加是否与AN骨折有关尚不清楚。我们对62名绝经前妇女进行了一项横断面研究，其中包括34名AN和28名相似年龄的正常体重妇女。在患者访谈期间收集骨折史，并通过DXA测量BMD，通过1H-MRS测量BMAT，通过HR-pQCT测量骨微结构参数。16名AN女性（47.1%）报告了既往骨折史，而11名正常体重女性（39.3%，p=0.54）报告了既往骨折史。在整个组和AN女性亚组中，有骨折史的女性与无骨折史的女性的BMD或骨微结构参数无显著差异。相比之下，有骨折史的AN女性在脊柱和股骨的BMAT高于无骨折史的女性（两者p=0.01）。与BMD和骨微结构参数相比，BMAT能够区分有骨折史的AN女性与无骨折史的AN女性。有必要进行前瞻性研究，以了解BMAT在AN骨折风险增加中的潜在病理生理作用。虽然神经性厌食症患者骨密度降低，骨折风险增加，但骨密度不能预测其骨折史。我们评估了神经性厌食症妇女的BMD、骨微结构和骨髓脂肪组织（BMAT），发现只有BMAT与骨折史相关。
Anorexia nervosa (AN) is a psychiatric disorder characterized by low body weight, low BMD and increased risk of fracture. Although BMD is reduced and fracture risk elevated, BMD as assessed by DXA does not distinguish between individuals with versus those without prior history of fracture in AN. Despite having decreased peripheral adipose tissue stores, individuals with AN have enhanced bone marrow adipose tissue (BMAT), which is inversely associated with BMD. Whether increased BMAT is associated with fracture in AN is not known. We conducted a cross-sectional study in 62 premenopausal women, including 34 with AN and 28 normal-weight women of similar age. Fracture history was collected during patient interviews and BMD measured by DXA, BMAT by 1H-MRS and parameters of bone microarchitecture by HR-pQCT. Sixteen women (47.1%) with AN reported prior history of fracture compared to 11 normal-weight women (39.3%, p=0.54). In the entire group and also the subset of women with AN, there were no significant differences in BMD or parameters of bone microarchitecture in women with prior fracture versus those without. In contrast, women with AN with prior fracture had greater BMAT at the spine and femur compared to those without (p=0.01 for both). In contrast to BMD and parameters of bone microarchitecture, BMAT is able to distinguish between women with AN with prior fracture compared to those without. Prospective studies will be necessary to understand BMAT’s potential pathophysiologic role in the increased fracture risk in AN. Although bone mineral density (BMD) is decreased and fracture risk increased in anorexia nervosa, BMD does not predict fracture history in this disorder. We assessed BMD, bone microarchitecture and bone marrow adipose tissue (BMAT) in women with anorexia nervosa and found that only BMAT was associated with fracture history.
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DOI：
10.1359/jbmr.090805
发表时间：
2010-02
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Ecklund K;Vajapeyam S;Feldman HA;Buzney CD;Mulkern RV;Kleinman PK;Rosen CJ;Gordon CM
通讯作者：
Gordon CM
影响因子：
5.5
作者：
Frolich, Jacob;Winkler, Laura A.;Stoving, Rene K.
通讯作者：
Stoving, Rene K.
影响因子：
6.2
作者：
Stone, KL;Seeley, DG;Cummings, SR
通讯作者：
Cummings, SR
影响因子：
6.2
作者：
Nagata, Jason M.;Golden, Neville H.;Denburg, Michelle R.
通讯作者：
Denburg, Michelle R.
影响因子：
3.8
作者：
Resulaj, Megi;Polineni, Sai;Fazeli, Pouneh K.
通讯作者：
Fazeli, Pouneh K.