The stage- and sex-specific transcriptome of the human parasite Schistosoma mansoni
The stage- and sex-specific transcriptome of the human parasite Schistosoma mansoni
复制标题
人类寄生虫曼氏血吸虫的阶段和性别特异性转录组
DOI：
10.1101/2023.05.02.539039
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Buddenborg S
中科院分区：
文献类型：
--
作者：
Buddenborg S
The flatwormSchistosoma mansoniis an important but neglected pathogen that causes the disease schistosomiasis in millions of people worldwide. The parasite has a complex life cycle, undergoing sexual reproduction in a mammalian host and asexual replication in a snail host. Understanding the molecular mechanisms that the parasite uses to transition between hosts and develop into dimorphic reproductively competent adults may reveal new strategies for control. We present the first comprehensive transcriptomic analysis ofS. mansoni, from eggs to sexually naïve worms. Focusing on eight life stages spanning free-living water-borne and parasitic stages from both intermediate and definitive hosts, we have generated deep RNA-seq data for five replicates per group for a total of 75 data sets. The data were produced using a single approach to increase the accuracy of stage-to-stage comparisons and made accessible via a user-friendly tool to visualise and explore gene expression (https://lifecycle.schisto.xyz/). These data are valuable for understanding the biology and sex-specific development of schistosomes and the interpretation of complementary genomic and functional genetics studies.
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曼氏血吸虫：皮肤和剪切压力衍生的血吸虫早期转化的超微结构。
影响因子：
2.1
作者：
C. Cousin;M. Stirewált;C. Dorsey
通讯作者：
C. Dorsey
哺乳动物体内发育过程中寄生扁虫曼氏血吸虫的转录组
DOI：
--
发表时间：
2019
期刊：
bioRxiv
影响因子：
--
作者：
Arporn Wangwiwatsin;Anna V. Protasio;Shona Wilson;C. Owusu;N. Holroyd;M. Sanders;Jacqueline A. Keane;M. Doenhoff;G. Rinaldi;M. Berriman
通讯作者：
M. Berriman
影响因子：
16.6
作者：
Li P;Nanes Sarfati D;Xue Y;Yu X;Tarashansky AJ;Quake SR;Wang B
通讯作者：
Wang B
影响因子：
16.6
作者：
Diaz Soria CL;Lee J;Chong T;Coghlan A;Tracey A;Young MD;Andrews T;Hall C;Ng BL;Rawlinson K;Doyle SR;Leonard S;Lu Z;Bennett HM;Rinaldi G;Newmark PA;Berriman M
通讯作者：
Berriman M
影响因子：
64.5
作者：
Hao Y;Hao S;Andersen-Nissen E;Mauck WM 3rd;Zheng S;Butler A;Lee MJ;Wilk AJ;Darby C;Zager M;Hoffman P;Stoeckius M;Papalexi E;Mimitou EP;Jain J;Srivastava A;Stuart T;Fleming LM;Yeung B;Rogers AJ;McElrath JM;Blish CA;Gottardo R;Smibert P;Satija R
通讯作者：
Satija R