Crosstalk signaling between alveoli and capillaries.

Crosstalk signaling between alveoli and capillaries.
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DOI:
10.1177/2045894018783735
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发表时间:
2018-07
影响因子:
2.6
通讯作者:
Bhattacharya J
Bhattacharya J
中科院分区:
医学4区
文献类型:
--
作者:
Hough RF;Bhattacharya S;Bhattacharya J

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肺泡的紧密并列的上皮和内皮膜之间的串扰信号传导建立了肺对吸入和血液传播的病原体的免疫防御。串扰可以发生在向前的方向上,如从肺泡到毛细血管,或者发生在相反的方向上,如从毛细血管到肺泡。串扰方向可能取决于病原体首先启动信号的部位。因此,当吸入的病原体遇到肺泡上皮时,可能发生正向串扰,而反向串扰可能由血液传播的病原体与内皮的相互作用引起。在这里,我们审查的因素,调节这两个方向的信号。
Crosstalk signaling between the closely juxtaposed epithelial and endothelial membranes of pulmonary alveoli establishes the lung’s immune defense against inhaled and blood-borne pathogens. The crosstalk can occur in a forward direction, as from alveolus to capillary, or in a reverse direction, as from capillary to alveolus. The crosstalk direction likely depends on the site at which pathogens first initiate signaling. Thus, forward crosstalk may occur when inhaled pathogens encounter the alveolar epithelium, while reverse crosstalk may result from interactions of blood-borne pathogens with the endothelium. Here, we review the factors that regulate these two directions of signaling.
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