NK Cell Subset Redistribution during the Course of Viral Infections.
NK Cell Subset Redistribution during the Course of Viral Infections.
复制标题
DOI：
10.3389/fimmu.2014.00390
复制
发表时间：
2014
影响因子：
7.3
通讯作者：
Mavilio D
中科院分区：
文献类型：
--
作者：
Lugli E;Marcenaro E;Mavilio D
自然杀伤（NK）细胞是先天免疫的重要效应细胞，在控制人类病毒感染中发挥关键作用。事实上，由于它们能够直接识别病毒感染的细胞而不需要特异性抗原呈递，NK细胞是抵御这些入侵病原体的第一道防线。通过与各种细胞类型（如树突状细胞）建立细胞网络，NK细胞还可以放大抗病毒适应性免疫应答。反过来，病毒进化并发展了几种机制来逃避NK细胞介导的免疫活性。据报道，某些病毒性疾病，包括人免疫缺陷病毒-1以及人巨细胞病毒感染，与外周血中NK细胞亚群的病理性重新分布有关。特别地，已经观察到非常规CD 56阴性NK细胞的扩增，与常规CD 56阳性NK细胞相比，其效应子功能显著受损。在这篇综述中，我们讨论了这两种慢性病毒感染对人类NK细胞功能和表型的影响。
Natural killer (NK) cells are important effectors of innate immunity that play a critical role in the control of human viral infections. Indeed, given their capability to directly recognize virally infected cells without the need of specific antigen presentation, NK cells are on the first line of defense against these invading pathogens. By establishing cellular networks with a variety of cell types such as dendritic cells, NK cells can also amplify anti-viral adaptive immune responses. In turn, viruses evolved and developed several mechanisms to evade NK cell-mediated immune activity. It has been reported that certain viral diseases, including human immunodeficiency virus-1 as well as human cytomegalovirus infections, are associated with a pathologic redistribution of NK cell subsets in the peripheral blood. In particular, it has been observed the expansion of unconventional CD56neg NK cells, whose effector functions are significantly impaired as compared to that of conventional CD56pos NK cells. In this review, we address the impact of these two chronic viral infections on the functional and phenotypic perturbations of human NK cell compartment.
登录
查看更多内容
影响因子：
32.4
作者：
Cosman, D;Müllberg, J;Chalupny, NJ
通讯作者：
Chalupny, NJ
影响因子：
20.3
作者：
Brunetta, Enrico;Fogli, Manuela;Mavilio, Domenico
通讯作者：
Mavilio, Domenico
影响因子：
3.4
作者：
Antonioli, CM;Airò, P
通讯作者：
Airò, P
DOI：
10.1073/pnas.1007654108
发表时间：
2010-12-14
影响因子：
11.1
作者：
Bellora, Francesca;Castriconi, Roberta;Bottino, Cristina
通讯作者：
Bottino, Cristina
影响因子：
20.3
作者：
Costantini, Claudio;Calzetti, Federica;Cassatella, Marco A.
通讯作者：
Cassatella, Marco A.