Neuropeptidergic integration of behavior in Trichoplax adhaerens, an animal without synapses.
Neuropeptidergic integration of behavior in Trichoplax adhaerens, an animal without synapses.
复制标题
DOI：
10.1242/jeb.162396
复制
发表时间：
2017-09-15
期刊：
影响因子：
--
通讯作者：
Smith CL
中科院分区：
文献类型：
--
作者：
Senatore A;Reese TS;Smith CL
Trichoplax adhaerens is a flat, millimeter-sized marine animal that adheres to surfaces and grazes on algae. Trichoplax displays a repertoire of different feeding behaviors despite the apparent absence of a true nervous system with electrical or chemical synapses. It glides along surfaces to find food, propelled by beating cilia on cells at its ventral surface, and pauses during feeding by arresting ciliary beating. We found that when endomorphin-like peptides are applied to an animal, ciliary beating is arrested, mimicking natural feeding pauses. Antibodies against these neuropeptides label cells that express the neurosecretory proteins and voltage-gated calcium channels implicated in regulated secretion. These cells are embedded in the ventral epithelium, where they comprise only 4% of the total, and are concentrated around the edge of the animal. Each bears a cilium likely to be chemosensory and used to detect algae. Trichoplax pausing during feeding or spontaneously in the absence of food often induce their neighbors to pause as well, even neighbors not in direct contact. Pausing behavior propagates from animal to animal across distances much greater than the signal that diffuses from just one animal, so we presume that the peptides secreted from one animal elicit secretion from nearby animals. Signal amplification by peptide-induced peptide secretion explains how a small number of sensory secretory cells lacking processes and synapses can evoke a wave of peptide secretion across the entire animal to globally arrest ciliary beating and allow pausing during feeding. Trichoplax, a primitive marine animal that lacks neurons and synapses, has neurosecretory cells that secrete a peptide into the ambient seawater to arrest ciliary beating during feeding.
登录
查看更多内容
影响因子：
5.2
作者：
Caers J;Verlinden H;Zels S;Vandersmissen HP;Vuerinckx K;Schoofs L
通讯作者：
Schoofs L
影响因子：
7.8
作者：
DEVREOTES, PN;STECK, TL
通讯作者：
STECK, TL
影响因子：
7.7
作者：
Alegado RA;Brown LW;Cao S;Dermenjian RK;Zuzow R;Fairclough SR;Clardy J;King N
通讯作者：
King N
DOI：
10.1073/pnas.1106189108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Burkhardt, Pawel;Stegmann, Christian M.;Fasshauer, Dirk
通讯作者：
Fasshauer, Dirk
DOI：
10.1098/rspb.2009.0896
发表时间：
2009-12-22
影响因子：
4.7
作者：
Hejnol, Andreas;Obst, Matthias;Dunn, Casey W.
通讯作者：
Dunn, Casey W.