Contrast echocardiographic estimation of regional myocardial blood flow after acute coronary occlusion.
Contrast echocardiographic estimation of regional myocardial blood flow after acute coronary occlusion.
复制标题
急性冠状动脉闭塞后局部心肌血流的对比超声心动图评估。
作者：
A. Kemper;T. Force;R. Kloner;M. Gilfoil;L. Perkins;S. Hale;K. Alker;A. Parisi
对比超声心动图可以预测急性冠状动脉闭塞期间危险的病理区域。在本研究中，我们评估了（1）缺血区域造影剂出现的强度和时间是否可以提供残余心肌灌注的定量测量，以及（2）连续注射后观察到的这些参数的变化是否反映了急性缺血组织血流的变化。在急性回旋支冠状动脉闭塞后 1、20 和 120 分钟，对 12 只狗连续进行主动脉上过氧化氢对比超声心动图检查。对比度增强通过基于对比度增强的出现时间和峰值感知强度的分段四点评分系统定性确定，并通过设计用于反映这些参数的计算机算法定量确定。在每个节段中对伴随的放射性微球血流进行比较。定性评分系统地与归一化节段血流量相关（3+ = 93%；2+ = 61%；1+ = 32%；0 = 18%；每个与相邻值的 p 小于 0.01），定量分析包括所有节段（r = .78；p 小于 0.01）并隔离至缺血区域（流量 = 1.13 强度变化 +6.8%；r = .83， p 小于 0.001）。连续观察之间缺血区域微球流量的变化与定性评分的变化（r = .88，p 小于 0.001）和定量分析结果（r = 0.70，p 小于 0.01）相关。对比度增强量可以提供有关缺血区域残余心肌血流的定量信息，也可以用于跟踪急性冠状动脉闭塞后体内血流模式的变化。
Contrast echocardiography can predict pathologic area at risk during acute coronary occlusion. In this study we evaluated (1) whether the intensity and timing of contrast appearance in ischemic regions can provide a quantitative measure of residual myocardial perfusion, and (2) whether changes in these parameters observed after serial injections reflect changes in blood flow to acutely ischemic tissue. Supra-aortic hydrogen peroxide contrast echocardiography was performed in 12 consecutive dogs at 1, 20, and 120 min after acute circumflex coronary occlusion. Contrast enhancement was determined qualitatively with a segmental four-point scoring system based on the appearance time and peak perceived intensity of contrast enhancement and quantitatively with a computer algorithm designed to reflect these parameters. Comparison was made in each segment to concomitant radioactive microsphere blood flow. Qualitative scoring related systematically to normalized segmental blood flow (3+ = 93%; 2+ = 61%; 1+ = 32%; 0 = 18%; p less than .01 for each vs adjacent value), as did quantitative analysis including all segments (r = .78; p less than .01) and isolated to the ischemic region (flow = 1.13 intensity change +6.8%; r = .83, p less than .001). Changes in microsphere flow in ischemic regions between sequential observations were correlated with changes in qualitative score (r = .88, p less than .001) and results of quantitative analysis (r = 0.70, p less than .01). The amount of contrast enhancement can provide quantitative information about residual myocardial blood flow in ischemic regions and can also be used to track changing patterns of flow in vivo after acute coronary occlusion.
DOI：
10.1016/s0735-1097(84)80424-6
发表时间：
1984-01-01
影响因子：
24
作者：
FEINSTEIN, SB;TENCATE, FJ;CORDAY, E
通讯作者：
CORDAY, E
心肌梗死患者再灌注后左心室功能的恢复：次全狭窄或完整侧支循环的重要性。
影响因子：
37.8
作者：
Rogers,WJ;HoodJr,WP;Mantle,JA;Baxley,WA;Kirklin,JK;Zorn,GL;Nath,HP
通讯作者：
Nath,HP