Multiple functions of hypoxia-regulated miR-210 in cancer.
Multiple functions of hypoxia-regulated miR-210 in cancer.
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缺氧调节的 miR-210 在癌症中的多种功能。
DOI：
10.1186/1756-9966-33-50
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发表时间：
2014-06-09
期刊：
影响因子：
--
通讯作者：
Baosheng L
中科院分区：
文献类型：
--
作者：
Qin Q;Furong W;Baosheng L
microRNA（miRNAs）是一类转录后调节基因表达的非编码小RNA。miRNAs可由多种应激（如缺氧）诱导，并参与多种生物学过程，包括分化、细胞增殖、细胞死亡和肿瘤发生。缺氧是肿瘤微环境的一个共同特征，可诱导多种miRNAs表达。miRNA-210（miR-210）是一种低氧调节的miRNA，在肿瘤中已被广泛研究。然而，关于它是癌基因还是肿瘤抑制基因，以及它是阳性还是阴性预后生物标志物，记录了矛盾的相反结果。本文就miR-210的癌基因功能、抑癌基因功能、线粒体代谢功能以及miR-210在肿瘤诊断和预后中的价值进行综述。
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. miRNAs can be induced by a variety of stresses such as hypoxia, and are involved in diverse biological processes including differentiation, cell proliferation, cell death, and tumorigenesis. Hypoxia, a common feature of tumor microenvironment, can induce a number of miRNAs expression. miRNA-210 (miR-210) is one of the hypoxia-regulated-miRNAs, which has been investigated extensively in cancer. However, paradoxically opposing results were documented regarding whether it is an oncogene or a tumor suppressor, and whether it is a positive or negative prognostic biomarker. In the present review, we focus on the following investigations of miR-210: 1) its functions of as an oncogene, 2) its functions as a tumor suppressor, 3) its functions in mitochondrial metabolism, and finally, the diagnostic and prognostic value of miR-210 in cancer researches.
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DOI：
10.4161/cc.9.6.11006
发表时间：
2010-03-15
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Chan SY;Loscalzo J
通讯作者：
Loscalzo J
影响因子：
3.7
作者：
Favaro E;Ramachandran A;McCormick R;Gee H;Blancher C;Crosby M;Devlin C;Blick C;Buffa F;Li JL;Vojnovic B;Pires das Neves R;Glazer P;Iborra F;Ivan M;Ragoussis J;Harris AL
通讯作者：
Harris AL
影响因子：
3.4
作者：
Cai, Haiqing;Lin, Lijun;Wang, Zhigang
通讯作者：
Wang, Zhigang
DOI：
10.1073/pnas.1001653107
发表时间：
2010-04-13
影响因子：
11.1
作者：
Biswas, Sabyasachi;Roy, Sashwati;Sen, Chandan K.
通讯作者：
Sen, Chandan K.
影响因子：
6.2
作者：
Elf SE;Chen J
通讯作者：
Chen J