Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats.
Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats.
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有机和无机硒化合物在大鼠血浆中产生不同的蛋白质模式。
DOI：
10.4067/s0716-97602009000200004
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发表时间：
2009
影响因子：
6.7
通讯作者：
M. Ruz
中科院分区：
文献类型：
--
作者：
A. Mahn;H. Toledo;M. Ruz
一些硒化合物在以超营养剂量给药时提供重要的健康益处，例如改善免疫系统和男性生育能力，以及预防某些类型的癌症。传统的硒代谢指标不能反映高硒个体的硒代谢状况。因此，需要区分硒的补充状态的新指标。本工作的目的是确定一些血浆蛋白，响应超营养剂量的硒，这可能是建议作为新的蛋白质标记物的硒摄入量。本文研究了硒甲基硒代半胱氨酸（SMSeC）和硒酸钠对大鼠血浆蛋白的影响。两个实验组，每组6只大鼠，分别喂养的基础饮食补充SMSeC或硒酸钠在1.9微克硒/克饮食10周。对照组喂食含有推荐硒剂量（0.15微克硒/克饮食）的饮食。对一组血浆蛋白丰度的变化进行定量和统计分析。结合珠蛋白，载脂蛋白E和甲状腺素运载蛋白增加了他们的丰富后，饮食补充任何形式的硒。HNF 6仅对SMSeC有反应，而纤维蛋白原仅对硒酸钠有反应。我们假设，在这项工作中观察到的蛋白质模式可以提出作为新的分子生物学为基础的硒摄入量的标志物。
Some selenium compounds offer important health benefits when administered at supranutritional doses, such as improvement of the immune system and of male fertility, and the prevention of some types of cancer. The traditional selenium indexes do not account for the metabolic status of this element among replete individuals. As a consequence, there is a need for new indexes that distinguish between repletion statuses of selenium. The aim of this work was to identify some plasmatic proteins that respond to supranutritional doses of selenium, which could be proposed as new protein markers of selenium intake. The effect on rats of dietary supplementation with either selenomethylselenocysteine (SMSeC) or sodium-selenate on some blood plasma proteins was investigated. Two experimental groups consisting of six rats each were fed a basic diet supplemented with either SMSeC or sodium-selenate at 1.9 microg-Se / g-diet for ten weeks. The control group was fed a diet that contained the recommended selenium dose (0.15 microg-Se / g-diet). The changes in the abundance of a group of plasmatic proteins were quantified and analysed statistically. Haptoglobin, apolipoprotein E and transthyretin increased their abundance after diet supplementation with either form of selenium. HNF6 was responsive only to SMSeC, whereas fibrinogen responded only to sodium-selenate. We postulate that the protein patterns observed in this work could be proposed as new molecular biology-based markers of selenium intake.
DOI：
10.1046/j.1464-410x.1998.00630.x
发表时间：
1998-05
期刊：
British journal of urology
影响因子：
--
作者：
L. Clark;Bruce L. Dalkin;A. Krongrad;G. Combs;B. Turnbull;E. Slate;R. Witherington;Herlong Jh
通讯作者：
L. Clark;Bruce L. Dalkin;A. Krongrad;G. Combs;B. Turnbull;E. Slate;R. Witherington;Herlong Jh
健康英国成年人的纵向硒状况：使用生化和分子生物标志物进行评估。
DOI：
10.1017/s0007114508006831
发表时间：
2008
期刊：
The British journal of nutrition
影响因子：
--
作者：
Sunde,RogerA;Paterson,Elaine;Evenson,JacquelineK;Barnes,KimberlyM;Lovegrove,JulieA;Gordon,MichaelH
通讯作者：
Gordon,MichaelH
影响因子：
--
作者：
Hurwitz, Barry E.;Klaus, Johanna R.;Schneiderman, Neil
通讯作者：
Schneiderman, Neil