INTERFEROME: the database of interferon regulated genes.

INTERFEROME: the database of interferon regulated genes.
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DOI:
10.1093/nar/gkn732
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发表时间:
2009-01
影响因子:
14.9
通讯作者:
Hertzog PJ
Hertzog PJ
中科院分区:
生物学2区
文献类型:
--
作者:
Samarajiwa SA;Forster S;Auchettl K;Hertzog PJ

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INTERFEROME 是 I、II 和 III 型干扰素调节基因的开放获取数据库 (http://www.interferome.org),通过分析用 IFN 处理的细胞的表达数据集收集。该干扰素调控基因数据库整合了来自高通量实验的信息,以及来自 37 个物种的注释、本体论、直系同源序列、组织表达模式和基因调控信息,以便能够详细研究干扰素生物学的分子机制。 INTERFEROME 通过提供计算工具来帮助识别高通量表达技术生成的基因列表中的干扰素特征及其潜在的分子和生物学后果,从而满足感染、免疫、发育和癌症研究的需求。
INTERFEROME is an open access database of types I, II and III Interferon regulated genes (http://www.interferome.org) collected from analysing expression data sets of cells treated with IFNs. This database of interferon regulated genes integrates information from high-throughput experiments with annotation, ontology, orthologue sequences from 37 species, tissue expression patterns and gene regulatory information to enable a detailed investigation of the molecular mechanisms underlying IFN biology. INTERFEROME fulfils a need in infection, immunity, development and cancer research by providing computational tools to assist in identifying interferon signatures in gene lists generated by high-throughput expression technologies, and their potential molecular and biological consequences.
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