Exosomes from Human Synovial-Derived Mesenchymal Stem Cells Prevent Glucocorticoid-Induced Osteonecrosis of the Femoral Head in the Rat.
Exosomes from Human Synovial-Derived Mesenchymal Stem Cells Prevent Glucocorticoid-Induced Osteonecrosis of the Femoral Head in the Rat.
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来自人类滑膜来源的间充质干细胞的外泌体可预防糖皮质激素诱导的大鼠股骨头坏死
DOI：
10.7150/ijbs.16150
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发表时间：
2016
影响因子：
9.2
通讯作者：
Zhang CQ
中科院分区：
文献类型：
--
作者：
Guo SC;Tao SC;Yin WJ;Qi X;Sheng JG;Zhang CQ
股骨头坏死(ONFH)是糖皮质激素(GC)治疗后的一种使人衰弱的并发症。滑膜间充质干细胞(SMSCs)在GC诱导的ONFH动物模型中可通过诱导细胞增殖、防止细胞凋亡而发挥保护作用。最近的研究表明，移植的细胞主要通过旁分泌机制发挥治疗作用，外泌体是一种重要的旁分泌因子，可以直接用作组织工程的治疗剂。在此，我们首次证明了早期治疗人滑膜间充质干细胞(SMSC-Exos)分泌的外切体可以预防GC诱导的大鼠ONFH。通过一系列的体外功能分析，我们发现SMSC-Exos可以内化到骨髓基质细胞(BMSCs)中，促进其增殖，并具有抗凋亡的能力。最后，SMSC-Exos可能在预防GC诱导的ONFH方面有希望。
Osteonecrosis of the femoral head (ONFH) represents a debilitating complication following glucocorticoid (GC)-based therapy. Synovial-derived mesenchymal stem cells (SMSCs) can exert protective effect in the animal model of GC-induced ONFH by inducing cell proliferation and preventing cell apoptosis. Recent studies indicate the transplanted cells exert therapeutic effects primarily via a paracrine mechanism and exosomes are an important paracrine factor that can be directly used as therapeutic agents for tissue engineering. Herein, we provided the first demonstration that the early treatment of exosomes secreted by human synovial-derived mesenchymal stem cells (SMSC-Exos) could prevent GC-induced ONFH in the rat model. Using a series of in vitro functional assays, we found that SMSC-Exos could be internalized into bone marrow derived stromal cells (BMSCs) and enhance their proliferation and have anti-apoptotic abilities. Finally, SMSC-Exos may be promising for preventing GC-induced ONFH.
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影响因子：
9.7
作者：
Munagala R;Aqil F;Jeyabalan J;Gupta RC
通讯作者：
Gupta RC
影响因子：
1
作者：
Hernigou P;Poignard A;Zilber S;Rouard H
通讯作者：
Rouard H
影响因子：
7.4
作者：
Choudhery MS;Badowski M;Muise A;Pierce J;Harris DT
通讯作者：
Harris DT
影响因子：
2.5
作者：
Hernigou P;Trousselier M;Roubineau F;Bouthors C;Chevallier N;Rouard H;Flouzat-Lachaniette CH
通讯作者：
Flouzat-Lachaniette CH
DOI：
10.2174/1874325001206010449
发表时间：
2012-01-01
期刊：
The open orthopaedics journal
影响因子：
--
作者：
Chan, K L;Mok, C C
通讯作者：
Mok, C C