Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak.
Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak.
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COVID-19 爆发中无症状传播的系统基因组追踪
DOI：
10.1016/j.xinn.2021.100099
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发表时间：
2021-05-28
期刊：
影响因子：
--
通讯作者：
Zeng H
中科院分区：
文献类型：
--
作者：
Zhang J;Ding N;Song Y;Song R;Pan Y;Wang L;Yan S;Wang Q;Ma S;Wei L;Yu F;Lu L;Zhang F;Chen C;Zeng H
SARS-CoV-2已造成1亿多人死亡，并继续在世界各地迅速传播。SARS-CoV-2的无症状传播是新冠肺炎公共卫生控制措施的致命弱点。SARS-CoV-2的系统基因组学数据可以为无症状传播提供更直接的信息。在这项研究中，我们使用一种新的Minerva测序技术，追踪了北京新冠肺炎患者中国的无症状传播。178名密切接触者被隔离，14名新冠肺炎患者经RT-PCR法实验室确诊。我们通过构建簇中的中间连接网络，为无症状传播提供了直接的系统基因组学证据。这些数据可以帮助我们确定目前的基于症状的筛查是否应该涵盖无症状的人。SARS-CoV-2的无声传播对公众健康构成威胁新的Minerva测序技术揭示了SARS-CoV-2在无症状传播过程中病毒变异的积累与无症状新冠肺炎患者的密切接触可发展为有症状患者，系统基因组学追踪可有效地支持新冠肺炎疫情的调查
SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world. Asymptomatic transmission of SARS-CoV-2 is the Achilles’ heel of COVID-19 public health control measures. Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmission. In this study, using a novel MINERVA sequencing technology, we traced asymptomatic transmission of COVID-19 patients in Beijing, China. One hundred and seventy-eight close contacts were quarantined, and 14 COVID-19 patients were laboratory confirmed by RT-PCR. We provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster. These data could help us to determine whether the current symptom-based screening should cover asymptomatic persons. The silent transmission of SARS-CoV-2 poses a threat to public health The novel MINERVA sequencing technology reveals the accumulation of viral mutations during the asymptomatic transmission of SARS-CoV-2 Close contacts of asymptomatic COVID-19 cases could develop into symptomatic patients Phylogenomic tracing could efficiently support the epidemic investigations of the COVID-19 outbreak
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