FNDC4 acts as an extracellular factor to promote the invasiveness of hepatocellular carcinoma partly via the PI3K/Akt signalling pathway.
FNDC4 acts as an extracellular factor to promote the invasiveness of hepatocellular carcinoma partly via the PI3K/Akt signalling pathway.
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DOI：
10.1002/cam4.4225
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发表时间：
2021-10
期刊：
影响因子：
4
通讯作者：
Zheng S
中科院分区：
文献类型：
--
作者：
Wang B;Zheng B;Lu Y;Huang D;Liu J;Song J;Zheng S
FNDC4与运动相关的肌动蛋白FNDC5/Irisin高度同源，高表达并促进肝癌细胞的侵袭和转移。然而，FNDC4基因的功能仍不清楚。在此，我们报道了细胞外因子FNDC4在肝细胞癌的侵袭和转移中起重要作用。我们发现，FNDC4的高表达与肝癌患者的生存不良有关，并且FNDC4促进了肝癌细胞的迁移和侵袭。从机制上讲，我们发现FNDC4与PI3K/Akt信号通路有一定的相关性。具体地说，FNDC4的胞外区作为一个胞外因子促进该途径中Akt的磷酸化水平。这些发现表明，FNDC4促进肝癌的侵袭和转移部分是通过PI3K/Akt信号通路实现的。FNDC4在人肝细胞癌组织中存在差异表达，其高表达与肝细胞癌预后不良密切相关。
FNDC4 is highly homologous to the exercise‐associated myokine FNDC5/irisin, which is highly expressed and promotes the invasion and metastasis of HCC cells. However, the function of FNDC4 remains unknown. Here, we report that FNDC4, an extracellular factor, plays important roles in the invasion and metastasis of HCC. We found that high FNDC4 expression is associated with poor survival in HCC patients and FNDC4 promotes the migration and invasion of HCC cells. Mechanistically, we found that FNDC4 is related to the PI3K/Akt signalling pathway to a certain extent. Specifically, the extracellular domain of FNDC4 acts as an extracellular factor to promote Akt phosphorylation levels in this pathway. These findings reveal that FNDC4 promotes the invasion and metastasis of HCC partly via the PI3K/Akt signalling pathway. FNDC4 is differentially expressed in human HCC tissues, and high FNDC4 expression is significantly related to the poor prognosis of HCC.
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影响因子：
16.6
作者：
Bosma M;Gerling M;Pasto J;Georgiadi A;Graham E;Shilkova O;Iwata Y;Almer S;Söderman J;Toftgård R;Wermeling F;Boström EA;Boström PA
通讯作者：
Boström PA
影响因子：
3.9
作者：
Zheng M;Jones DM;Horzempa C;Prasad A;McKeown-Longo PJ
通讯作者：
McKeown-Longo PJ
DOI：
10.1038/jid.2010.253
发表时间：
2011-01
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.8
作者：
Fruhbeck, Gema;Fernandez-Quintana, Blanca;Rodriguez, Amaia
通讯作者：
Rodriguez, Amaia
影响因子：
254.7
作者：
OBERFIELD, RA;STEELE, G;SHERMAN, D
通讯作者：
SHERMAN, D