'Gut health': a new objective in medicine?
'Gut health': a new objective in medicine?
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DOI：
10.1186/1741-7015-9-24
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发表时间：
2011-03-14
期刊：
影响因子：
9.3
通讯作者：
Bischoff SC
中科院分区：
文献类型：
--
作者：
Bischoff SC
“肠道健康”是一个越来越多地在医学文献和食品工业中使用的术语。它涵盖了胃肠道（GI）的多个积极方面，例如食物的有效消化和吸收，没有GI疾病，正常和稳定的肠道微生物群，有效的免疫状态和健康状态。然而，从科学的角度来看，肠道健康究竟是什么，如何定义以及如何测量仍然非常不清楚。与GI微生物群相邻的GI屏障似乎是理解维持肠道健康的复杂机制的关键。胃肠道屏障的任何损伤都可能增加发生感染性、炎症性和功能性胃肠道疾病以及肠外疾病（如免疫介导的疾病和代谢疾病）的风险。然而，不太清楚的是，一般的胃肠道不适是否也与胃肠道屏障功能有关。在任何情况下，评估，改善和维持肠道健康相关的GI功能的方法是预防医学的主要兴趣。
'Gut health' is a term increasingly used in the medical literature and by the food industry. It covers multiple positive aspects of the gastrointestinal (GI) tract, such as the effective digestion and absorption of food, the absence of GI illness, normal and stable intestinal microbiota, effective immune status and a state of well-being. From a scientific point of view, however, it is still extremely unclear exactly what gut health is, how it can be defined and how it can be measured. The GI barrier adjacent to the GI microbiota appears to be the key to understanding the complex mechanisms that maintain gut health. Any impairment of the GI barrier can increase the risk of developing infectious, inflammatory and functional GI diseases, as well as extraintestinal diseases such as immune-mediated and metabolic disorders. Less clear, however, is whether GI discomfort in general can also be related to GI barrier functions. In any case, methods of assessing, improving and maintaining gut health-related GI functions are of major interest in preventive medicine.
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