EPB41L3 is a potential tumor suppressor gene and prognostic indicator in esophageal squamous cell carcinoma.
EPB41L3 is a potential tumor suppressor gene and prognostic indicator in esophageal squamous cell carcinoma.
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DOI：
10.3892/ijo.2018.4316
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发表时间：
2018-05
影响因子：
5.2
通讯作者：
Zheng YF
中科院分区：
文献类型：
--
作者：
Zeng R;Liu Y;Jiang ZJ;Huang JP;Wang Y;Li XF;Xiong WB;Wu XC;Zhang JR;Wang QE;Zheng YF
尽管已有研究报道红细胞膜蛋白带4.1L3(EPB41L3)在多种肿瘤中的作用，但EPB41L3的分子功能和调控机制尚不清楚。具体地说，EPB41L3在食管鳞癌中的功能和临床意义尚未被探讨。在本研究中，EPB41L3在ESCC细胞系和组织中的表达降低，这是由于其高甲基化速率所致。EPB41L3在ESCC细胞中的异位表达在体内和体外均能抑制细胞的增殖。此外，EPB41L3过表达通过激活Caspase-3/8/9和Cyclin依赖的激酶1/Cyclin B1信号分别诱导细胞凋亡和G2/M期停滞。值得注意的是，EPB41L3高表达患者的总生存率明显高于EPB41L3低表达患者。综上所述，本研究结果提示EPB41L3基因可能是食管癌发生发展过程中的抑癌基因，是食管癌潜在的治疗靶点和预后指标。
Although there have been reports about the role of erythrocyte membrane protein band 4.1 like 3 (EPB41L3) in several types of cancer, primarily in non-small-cell lung carcinoma, the molecular function and modulatory mechanisms of EPB41L3 remain unclear. In specific, the functional and clinical significance of EPB41L3 in esophageal squamous cell carcinoma (ESCC) has not been explored to date. In the present study, reduced EPB41L3 expression was demonstrated in ESCC cell lines and tissues, which was due to its high methylation rate. Ectopic expression of EPB41L3 in ESCC cells inhibited cell proliferation in vivo and in vitro. In addition, EPB41L3 overexpression induced apoptosis and G2/M cell cycle arrest by activating Caspase-3/8/9 and Cyclin-dependent kinase 1/Cyclin B1 signaling, respectively. Notably, patients with higher EPB41L3 expression had markedly higher overall survival rates compared with patients with lower EPB41L3 expression. In summary, the present results suggest that EPB41L3 may be a tumor suppressor gene in ESCC development, representing a potential therapeutic target and a prognostic indicator for ESCC.
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影响因子：
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