Separation of airway and tissue properties by transfer respiratory impedance and thoracic gas volume in reversible airway obstruction.
Separation of airway and tissue properties by transfer respiratory impedance and thoracic gas volume in reversible airway obstruction.
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通过可逆性气道阻塞中的转移呼吸阻抗和胸廓气体量来分离气道和组织特性。
DOI：
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发表时间：
1996
影响因子：
24.3
通讯作者：
R. Peslin
中科院分区：
文献类型：
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作者：
F. Marchal;N. Bouaziz;C. Baeyert;C. Gallina;C. Duvivier;R. Peslin
本研究的目的是建立能力，估计单独的气道和组织属性的传输呼吸阻抗（Zrs，tr）的数据存在气道阻塞。对13例正常或无症状哮喘成人和28例有症状哮喘儿童在阻塞和使用支气管扩张剂（BD）后的Zrs、Tr、胸气量（TGV）和气道阻力（Raw，pleth）进行了测定。使用分析方法来求解DuBois模型的简化变体的方程，包括气道阻力（Raw*）和惯性（Iaw）、组织顺应性（Ct）和阻力（Rt）以及肺气体顺应性（Cg）。在BD之前，该模型的方程在四个儿童中不能可靠地求解。平均Raw，pleth与之前成人的平均Raw* 无差异（平均值+/- SEM）（3.4 +/- 0.5 vs 3.1 +/- 0.3 hPa.s.L-1）或BD后（1.4 +/- 0.2 vs 1.8 +/- 0.2 hPa.s.L-1）或BD后儿童（分别为2.9 +/- 0.3 vs 3.2 +/- 0.2 hPa.s.L-1）。在BD之前的儿童中，与原始体积描记图相比，原始体积描记图 * 被显著低估（3.8 +/- 0.4 vs 5.4 +/- 0.6 hPa.s.L-1）。总体而言，发现差异[Raw，pleth - Raw*]和Raw，pleth（r = 0.82）之间存在显著正相关。在成人中，BD诱导Raw* 和Rt降低，Ct增加，Iaw无变化。在BD后的儿童中，Raw* 或Ct无显著变化，而Rt降低，Iaw增加。以Raw、pleth为金标准，得出结论：在正常人和中度气道阻塞的成人中，联合测量Zrs、tr和TGV可获得DuBois模型参数的一致估计，而在严重气道阻塞的儿童中则不能。这似乎是由于对Raw* 的系统性低估。
The aim of this study was to establish the ability to estimate separate airway and tissue properties from transfer respiratory impedance (Zrs,tr) data in the presence of airway obstruction. Zrs,tr, thoracic gas volume (TGV) and airway resistance (Raw,pleth) were measured in the presence of obstruction and after use of a bronchodilator (BD) in 13 normal or asymptomatic asthmatic adults and 28 children with symptomatic asthma. An analytical approach was used to solve the equations of a simplified variant of DuBois' model, including airway resistance (Raw*) and inertance (Iaw), tissue compliance (Ct) and resistance (Rt) and pulmonary gas compliance (Cg). The equations of the model could not be reliably solved in four children before BD. Mean Raw,pleth was not different from mean Raw* in adults before (mean +/- SEM) (3.4 +/- 0.5 vs 3.1 +/- 0.3 hPa.s.L-1) or after BD (1.4 +/- 0.2 vs 1.8 +/- 0.2 hPa.s.L-1), or in children after BD (2.9 +/- 0.3 vs 3.2 +/- 0.2 hPa.s.L-1, respectively). In children before BD, Raw* was significantly underestimated compared with Raw,pleth (3.8 +/- 0.4 vs 5.4 +/- 0.6 hPa.s.L-1). Overall, a significant positive correlation was found between the difference [Raw,pleth - Raw*] and Raw,pleth (r = 0.82). In adults, BD induced a decrease in Raw* and Rt, an increase in Ct, and no change in Iaw. In children after BD, there was no significant change in Raw* or Ct, whilst Rt decreased and Iaw increased. Taking Raw,pleth as the gold standard, it is concluded that coherent estimation of parameters of DuBois' model may be obtained from combined Zrs,tr and TGV measurements in normal subjects and moderately obstructed adults, but not in children with significant airway obstruction. This seems to be due to the systematic under-estimation of Raw*.
影响因子：
3.3
作者：
HANTOS, Z;DAROCZY, B;FREDBERG, JJ
通讯作者：
FREDBERG, JJ