Alterations in the megakaryocyte transcriptome impacts platelet function in sepsis and COVID-19 infection.
Alterations in the megakaryocyte transcriptome impacts platelet function in sepsis and COVID-19 infection.
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DOI：
10.1016/j.thromres.2023.05.015
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发表时间：
2023-11
影响因子：
7.5
通讯作者：
Middleton, Elizabeth A.
中科院分区：
文献类型：
--
作者：
Ajanel, Abigail;Middleton, Elizabeth A.
血小板及其母细胞巨核细胞（MK）在感染和炎症过程中的作用越来越受到重视。MK驻留在骨髓中或从贩运到其他器官用于发育的前体产生，继续通过血小板生成形成血小板。感染，通过直接和间接的机制，可以改变MK的转录谱。环境的改变，无论是由炎症细胞因子还是其他信号机制介导，都会导致血小板转录组的改变。释放到循环中的血小板又与循环白细胞和内皮细胞相互作用，并通过免疫血栓形成等机制促进病原体的清除或病理生理学的增强。在这篇文章中，我们希望确定关键的贡献，探索在严重的，全身性的感染反应广泛定义为脓毒症和病毒感染，包括SARS-CoV 2的改变转录景观的影响。我们包括目前的出版物，概述了从骨髓和髓外网站以及循环血小板的MK的作用。基础疾病导致血栓性并发症，加重器官功能障碍和死亡率。了解血小板对疾病病理生理学的影响可能会推动治疗进展，以改善这些致命疾病的发病率和死亡率。
Platelets and their parent cell, the megakaryocyte (MK), are increasingly recognized for their roles during infection and inflammation. The MK residing in the bone marrow or arising from precursors trafficked to other organs for development go on to form platelets through thrombopoiesis. Infection, by direct and indirect mechanisms, can alter the transcriptional profile of MKs. The altered environment, whether mediated by inflammatory cytokines or other signaling mechanisms results in an altered platelet transcriptome. Platelets released into the circulation, in turn, interact with each other, circulating leukocytes and endothelial cells and contribute to the clearance of pathogens or the potentiation of pathophysiology through such mechanisms as immunothrombosis. In this article we hope to identify key contributions that explore the impact of an altered transcriptomic landscape during severe, systemic response to infection broadly defined as sepsis, and viral infections, including SARS-CoV2. We include current publications that outline the role of MKs from bone-marrow and extra-medullary sites as well as the circulating platelet. The underlying diseases result in thrombotic complications that exacerbate organ dysfunction and mortality. Understanding the impact of platelets on the pathophysiology of disease may drive therapeutic advances to improve the morbidity and mortality of these deadly afflictions.
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DOI：
10.1073/pnas.91.19.8767
发表时间：
1994-09-13
影响因子：
11.1
作者：
CELI, A;PELLEGRINI, G;FURIE, B
通讯作者：
FURIE, B
影响因子：
10.4
作者：
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通讯作者：
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DOI：
10.1161/01.atv.0000184765.59207.f3
发表时间：
2005-11-01
影响因子：
8.7
作者：
Chakrabarti, S;Varghese, S;Freedman, JE
通讯作者：
Freedman, JE
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny
炎症细胞因子肿瘤坏死因子α对巨核细胞生成和血小板产生的双功能作用
影响因子：
10.4
作者：
Chu, Tiantian;Hu, Shuhong;Wu, De-Pei
通讯作者：
Wu, De-Pei