Interaction between two cellular subpopulations of a rat colonic carcinoma when inoculated to the syngeneic host
Interaction between two cellular subpopulations of a rat colonic carcinoma when inoculated to the syngeneic host
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接种到同基因宿主时大鼠结肠癌的两个细胞亚群之间的相互作用
DOI：
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发表时间：
1985
影响因子：
6.4
通讯作者：
Françoise Martin
中科院分区：
文献类型：
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作者：
A. Caignard;Monique Martin;M. Michel;Françoise Martin
从一个单独的、化学诱导的大鼠结肠癌中，已经分离出两个肿瘤细胞亚群。当注射到同基因大鼠体内时，在大多数动物中，TR细胞会产生进展性肿瘤，而TS细胞不会产生肿瘤，也不会在30天内出现肿瘤消退。TS细胞抑制肿瘤的生长，无论它们是在TR细胞之前注射，还是同时注射，在不同的位置，或与TR细胞混合。来自排斥TS肿瘤的动物的淋巴和脾淋巴细胞也抑制了TR细胞的生长。另一方面，当TS细胞被注射到带有已建立的TR肿瘤的大鼠体内时，它们能够产生进展性肿瘤。荷瘤大鼠的淋巴结和脾细胞均能促进TS细胞的生长。这些结果表明，同一肿瘤中的癌细胞亚群通过对宿主免疫系统的影响而相互作用。整个肿瘤的生长可能不仅取决于每个组成亚群的生长潜力，而且还取决于亚群之间的相互作用。
From a single, chemically‐induced rat colonic carcinoma, two subpopulations of tumor cells have been isolated. When injected into syngeneic rats, TR cells give rise to progressive tumors in most of the animals, whereas TS cells give rise to no tumors or to tumors which regress in less than 30 days. TS cells inhibit the growth of TR tumors, whether they are injected before TR cells or simultaneously, at a different site or mixed with the TR cells. Lymph nodes and spleen lymphocytes from animals having rejected TS tumors also inhibit TR‐cell growth. On the other hand, TS cells are able to give rise to progressive tumors when they are injected into rats bearing established TR tumors. Lymph nodes and spleen cells of TR tumorbearing rats are able to enhance TS cell growth. These results suggest that subpopulations of cancer cells contained in the same tumor interact with each other through their effect on the host immune system. The growth of a whole tumor probably depends not only on the growth potential of each constituent subpopulation, but also on the interaction between the subpopulations themselves.
影响因子：
11.2
作者：
B. Miller;F. Miller;J. Leith;G. Heppner
通讯作者：
B. Miller;F. Miller;J. Leith;G. Heppner