Friend or Foe: Lipid Droplets as Organelles for Protein and Lipid Storage in Cellular Stress Response, Aging and Disease.
Friend or Foe: Lipid Droplets as Organelles for Protein and Lipid Storage in Cellular Stress Response, Aging and Disease.
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DOI：
10.3390/molecules25215053
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发表时间：
2020-10-30
期刊：
影响因子：
--
通讯作者：
Rinnerthaler M
中科院分区：
文献类型：
--
作者：
Geltinger F;Schartel L;Wiederstein M;Tevini J;Aigner E;Felder TK;Rinnerthaler M
长期以来，脂滴被认为是单纯的脂质储存细胞器。最近的证据表明，LDs实际上是不同的和动态的细胞器，具有专门的蛋白质组和功能，在许多细胞中的作用。因此，LD有助于细胞信号传导、蛋白质和脂质稳态、代谢疾病和炎症。与多种功能一致，LD与许多细胞器相互作用，包括线粒体、过氧化物酶体、溶酶体、内质网和细胞核。LD是高度移动的和动态的细胞器，运动性受损会破坏与其他细胞器的相互作用。细胞器间接触的减少导致多种病理生理学，并经常导致神经退行性疾病。接触不仅为线粒体和过氧化物酶体中的β-氧化提供脂质，还可能包括将有毒脂质以及错误折叠和有害蛋白质转移到LD。此外，当严重的蛋白毒性应激破坏蛋白酶体系统时，LD有助于去除蛋白质聚集体。在细胞脂质稳态失衡期间，LD也支持细胞解毒。LD功能的微调是至关重要的，许多疾病都与功能失调的LD有关。我们总结了目前对LD及其与细胞器相互作用的理解，为细胞应激，衰老炎症和各种疾病状态期间的有害蛋白质和脂质提供了储存场所。
Lipid droplets (LDs) were considered as a mere lipid storage organelle for a long time. Recent evidence suggests that LDs are in fact distinct and dynamic organelles with a specialized proteome and functions in many cellular roles. As such, LDs contribute to cellular signaling, protein and lipid homeostasis, metabolic diseases and inflammation. In line with the multitude of functions, LDs interact with many cellular organelles including mitochondria, peroxisomes, lysosomes, the endoplasmic reticulum and the nucleus. LDs are highly mobile and dynamic organelles and impaired motility disrupts the interaction with other organelles. The reduction of interorganelle contacts results in a multitude of pathophysiologies and frequently in neurodegenerative diseases. Contacts not only supply lipids for β-oxidation in mitochondria and peroxisomes, but also may include the transfer of toxic lipids as well as misfolded and harmful proteins to LDs. Furthermore, LDs assist in the removal of protein aggregates when severe proteotoxic stress overwhelms the proteasomal system. During imbalance of cellular lipid homeostasis, LDs also support cellular detoxification. Fine-tuning of LD function is of crucial importance and many diseases are associated with dysfunctional LDs. We summarize the current understanding of LDs and their interactions with organelles, providing a storage site for harmful proteins and lipids during cellular stress, aging inflammation and various disease states.
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DOI：
10.1016/j.bpg.2014.08.007
发表时间：
2014-10-01
影响因子：
3.2
作者：
Bosetti, Cristina;Turati, Federica;La Vecchia, Carlo
通讯作者：
La Vecchia, Carlo
影响因子：
64.5
作者：
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通讯作者：
Gould AP
DOI：
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发表时间：
2016-03
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
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通讯作者：
Betuing S
影响因子：
3.9
作者：
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通讯作者：
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影响因子：
--
作者：
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通讯作者：
Titorenko VI