Desynchronization boost by non-uniform coordinated reset stimulation in ensembles of pulse-coupled neurons.
Desynchronization boost by non-uniform coordinated reset stimulation in ensembles of pulse-coupled neurons.
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脉冲耦合神经元集合中的非均匀协调复位刺激通过非均匀协调的复位刺激提升。
DOI：
10.3389/fncom.2013.00063
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发表时间：
2013
影响因子：
3.2
通讯作者：
Tass PA
中科院分区：
文献类型：
--
作者：
Lücken L;Yanchuk S;Popovych OV;Tass PA
几种脑部疾病的特征在于异常的神经元同步。由于涉及复杂的动力学机制，对异常神经同步性的去同步化在理论上是令人信服的。我们在这里提出了一种新型的协调复位（CR）刺激。CR意味着在不同的神经元亚群处顺序地递送相位重置刺激，即，在刺激周期中有时等距分布。这种统一的时序模式似乎是直观的，实际上适用于迄今为止用于研究CR的神经网络模型。CR重置人口的不稳定的集群状态，从那里它通过一个despersized瞬态，如果不受干扰，最终dispersizing。相比之下，我们表明最佳刺激时间是不均匀的。使用具有相位响应曲线的弱脉冲耦合神经元的模型，我们提供了一种能够确定最佳刺激定时模式的方法，该最佳刺激定时模式在应用CR刺激之后基本上最大化去极化瞬态时间。该方法包括在低维脉冲耦合映射中对簇的优化搜索。因此，模型特定的非均匀间隔的集群状态导致相当长的去电离瞬变。有趣的是，这种非均匀CR刺激的去极化增强已经可以通过均匀CR定时模式的轻微修改来实现。我们的研究结果表明，刺激时间的不均匀性可以是CR刺激的校准过程中的一个有医学价值的参数，其中后者已成功地用于治疗帕金森病和耳鸣的临床和临床前研究。
Several brain diseases are characterized by abnormal neuronal synchronization. Desynchronization of abnormal neural synchrony is theoretically compelling because of the complex dynamical mechanisms involved. We here present a novel type of coordinated reset (CR) stimulation. CR means to deliver phase resetting stimuli at different neuronal sub-populations sequentially, i.e., at times equidistantly distributed in a stimulation cycle. This uniform timing pattern seems to be intuitive and actually applies to the neural network models used for the study of CR so far. CR resets the population to an unstable cluster state from where it passes through a desynchronized transient, eventually resynchronizing if left unperturbed. In contrast, we show that the optimal stimulation times are non-uniform. Using the model of weakly pulse-coupled neurons with phase response curves, we provide an approach that enables to determine optimal stimulation timing patterns that substantially maximize the desynchronized transient time following the application of CR stimulation. This approach includes an optimization search for clusters in a low-dimensional pulse coupled map. As a consequence, model-specific non-uniformly spaced cluster states cause considerably longer desynchronization transients. Intriguingly, such a desynchronization boost with non-uniform CR stimulation can already be achieved by only slight modifications of the uniform CR timing pattern. Our results suggest that the non-uniformness of the stimulation times can be a medically valuable parameter in the calibration procedure for CR stimulation, where the latter has successfully been used in clinical and pre-clinical studies for the treatment of Parkinson's disease and tinnitus.
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影响因子：
1.2
作者：
Feng, Xiao-Jiang;Shea-Brown, Eric;Rabitz, Herschel
通讯作者：
Rabitz, Herschel
影响因子：
2.9
作者：
Ermentrout, B
通讯作者：
Ermentrout, B
影响因子：
2.5
作者：
Farries, Michael A.;Wilson, Charles J.
通讯作者：
Wilson, Charles J.
影响因子：
1.9
作者：
Danzl, Per;Hespanha, Joao;Moehlis, Jeff
通讯作者：
Moehlis, Jeff
影响因子：
16.2
作者：
Feldman, DE
通讯作者：
Feldman, DE