Baseline factors related to endothelial cell loss following penetrating keratoplasty.
Baseline factors related to endothelial cell loss following penetrating keratoplasty.
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DOI：
10.1001/archophthalmol.2011.102
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发表时间：
2011-09
影响因子：
--
通讯作者：
Sugar, Alan
中科院分区：
文献类型：
--
作者：
Lass, Jonathan H.;Beck, Roy W.;Benetz, Beth Ann;Dontchev, Mariya;Gal, Robin L.;Holland, Edward J.;Kollman, Craig;Mannis, Mark J.;Price, Francis, Jr.;Raber, Irving;Stark, Walter;Stulting, R. Doyle;Sugar, Alan
确定影响中等风险病症（主要是 Fuchs 营养不良或人工晶状体/无晶状体角膜水肿）的穿透性角膜移植术后内皮细胞损失的基线（供体、受体、手术）因素。在角膜捐献者研究 (CDS) 参与者的子集 (n=567) 中，术前和术后内皮细胞密度 (ECD) 由中央读数中心确定。进行多变量回归分析来检查哪些基线因素与 ECD 随着时间的推移相关。较大的移植物 (p < 0.001)、较年轻的供体年龄 (p < 0.001) 和女性供体性别 (p = 0.004) 与随访期间较高的 ECD 显着相关。 5 年时，> 8 – 9 mm 移植物的平均内皮细胞损失率为 68%，7 - < 8 mm 移植物的平均内皮细胞损失率为 75%，直径 8.0mm 的移植物的平均内皮细胞损失率为 74%。来自女性捐赠者的移植物经历了 67% 的细胞损失，而来自男性捐赠者的移植物的细胞损失率为 72%。组织检索方法、捐献者死亡原因、糖尿病史以及从死亡到保存或手术的时间与 ECD 随时间的变化没有显着相关性 (n=567)。针对内皮功能障碍情况进行穿透性角膜移植术后，较大的供体移植物尺寸、较年轻的供体年龄和女性供体性别与五年内较高的 ECD 相关。该数据值得探索内皮角膜移植术后可能存在类似关联的可能性。
To identify baseline (donor, recipient, operative) factors that affect endothelial cell loss following penetrating keratoplasty for a moderate-risk condition (principally Fuchs’ dystrophy or pseudophakic/aphakic corneal edema). In a subset (n=567) of Cornea Donor Study (CDS) participants, preoperative and postoperative endothelial cell density (ECD) were determined by a central reading center. Multivariate regression analyses were performed to examine which baseline factors correlated with ECD over time. Larger grafts (p<0.001), younger donor age (p < 0.001) and female donor gender (p = 0.004) were significantly associated with higher ECD during follow up. Mean endothelial cell loss at 5 years was 68% for > 8 – 9 mm grafts, 75% for 7 - < 8 mm grafts and 74% for those grafts 8.0mm in diameter. Grafts from female donors experienced a 67% cell loss compared with a 72% cell loss among grafts from male donors. Method of tissue retrieval, donor cause of death, history of diabetes, and time from death to preservation or to surgery were not significantly associated with changes in ECD over time (n=567). Following penetrating keratoplasty for endothelial dysfunction conditions, larger donor graft size, younger donor age and female donor gender were associated with higher ECD over five years. This data warrants exploring the possibility that similar associations may exist following endothelial keratoplasty.
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影响因子：
2.8
作者：
Epstein, Andrew J.;de Castro, Terla N.;Rapuano, Christopher J.
通讯作者：
Rapuano, Christopher J.
影响因子：
13.7
作者：
Gal, Robin L.;Dontchev, Mariya;Verdier, David D.
通讯作者：
Verdier, David D.
影响因子：
13.7
作者：
Lass, Jonathan H.;Gal, Robin L.;Verdier, David D.
通讯作者：
Verdier, David D.
影响因子：
2
作者：
Benetz, BA;Gal, RL;Lass, JH
通讯作者：
Lass, JH
影响因子：
13.7
作者：
Price, Marianne O.;Price, Francis W., Jr.
通讯作者：
Price, Francis W., Jr.