COVID-19 in posttransplant patients-report of 2 cases.
COVID-19 in posttransplant patients-report of 2 cases.
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DOI：
10.1111/ajt.15896
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发表时间：
2020-07
期刊：
影响因子：
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中科院分区：
文献类型：
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2019冠状病毒病（COVID-19）自二零二零年三月起成为大流行病。我们在此描述2例移植后COVID-19感染病例。第一个是59岁的肾移植受者;第二个是51岁的异基因骨髓移植受者。两名患者在COVID-19感染前均接受免疫抑制剂治疗，移植物功能稳定。诊断为COVID-19后，停用免疫抑制剂，并开始甲基强的松龙和预防性抗生素治疗，但肺损伤进展。感染后两例患者的T细胞均极低。尽管给予了最大限度的机械辅助支持，但两例患者均死亡。因此，移植后COVID-19肺炎的预后不容乐观，仍需警惕。较低的T细胞计数可能是预后不良的替代指标。
Coronavirus Disease 2019 (COVID-19) has become a pandemic since March 2020. We describe here 2 cases of COVID-19 infection in a posttransplant setting. First one is a 59-year-old renal transplant recipient; the second is a 51-year-old allogeneic bone marrow transplant recipient. Both patients were on immunosuppressant therapy and had stable graft function before COVID-19 infection. After the diagnosis of COVID-19, immunosuppressive agents were discontinued and methylprednisolone with prophylactic antibiotics were initiated, however, the lung injury progressed. The T cells were extremely low in both patients after infection. Both patients died despite the maximal mechanical ventilatory support. Therefore, the prognosis of COVID-19 pneumonia following transplantation is not optimistic and remains guarded. Lower T cell count may be a surrogate for poor outcome.
影响因子：
11.8
作者：
Qin, Chuan;Zhou, Luoqi;Tian, Dai-Shi
通讯作者：
Tian, Dai-Shi
影响因子：
8.8
作者：
Zhu, Lan;Xu, Xizhen;Chen, Gang
通讯作者：
Chen, Gang
影响因子：
3.1
作者：
McMurray, RW;Harisdangkul, V
通讯作者：
Harisdangkul, V