Neonatal SARS-CoV-2 Infection: Practical Tips.

Neonatal SARS-CoV-2 Infection: Practical Tips.
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DOI:
10.3390/pathogens10050611
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发表时间:
2021-05-17
期刊:
Pathogens (Basel, Switzerland)
影响因子:
--
通讯作者:
On Behalf Of The Study Group Of Neonatal Infectious Diseases
On Behalf Of The Study Group Of Neonatal Infectious Diseases
中科院分区:
其他
文献类型:
--
作者:
Auriti C;De Rose DU;Mondì V;Stolfi I;Tzialla C;On Behalf Of The Study Group Of Neonatal Infectious Diseases

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最近在中国湖北省武汉市发生的病毒大流行导致了一种新的 β 冠状病毒物种的鉴定,这种病毒能够感染人类,即 2019-nCoV,后来命名为 SARS-CoV-2。 SARS-CoV-2 引起一种名为 COVID-19 的临床综合征,该综合征呈现从轻度上呼吸道感染到严重肺炎的一系列症状,并伴有急性呼吸窘迫综合征和频繁死亡。所有年龄组都容易受到感染,但儿童,尤其是婴儿,似乎部分幸免,其临床病程比其他年龄组更有利。目前尚无明确证据表明妊娠晚期患上 COVID-19 肺炎的妇女的胎儿存在垂直传播和 SARS-CoV-2 宫内感染,即使可能传播,母亲 SARS-CoV2 阳性也不需要剖腹产,也不排除婴儿同室管理的禁忌,并允许母乳喂养。本综述概述了该病毒的生物学、感染的发病机制,特别关注妊娠和新生儿年龄、新生儿和小婴儿感染的临床表现,并总结了目前关于 SARS-CoV2 感染或有感染该病毒风险的新生儿临床护理的国际建议。本次审查的主要目的是提供最新信息,特别关注围产期和新生儿期 COVID-19 感染的临床管理。
The recent viral pandemic in Wuhan, Hubei, China has led to the identification of a new species of beta-coronavirus, able to infect humans, the 2019-nCoV, later named SARS-CoV-2. SARS-CoV-2 causes a clinical syndrome named COVID-19, which presents with a spectrum of symptoms ranging from mild upper respiratory tract infection to severe pneumonia, with acute respiratory distress syndrome and frequent death. All age groups are susceptible to the infection, but children, especially infants, seem to be partially spared, having a more favorable clinical course than other age groups. There is currently no clear evidence showing vertical transmission and intrauterine SARS-CoV-2 infection in fetuses of women developing COVID-19 pneumonia in late pregnancy, and even if transmission is possible, the SARS-CoV2 positivity of the mother does not require delivery by caesarean section, does not contraindicate the management of the infant in rooming-in and allows breastfeeding. This review provides an overview on the biology of the virus, on the pathogenesis of the infection, with particular attention to pregnancy and neonatal age, on the clinical presentation of infection in newborns and young infants and summarizes the international recommendations currently available on the clinical care of neonates with SARS-CoV2 infection or at risk of catching the virus. The main objective of the review is to provide an update especially focused to the clinical management of COVID-19 infection in the perinatal and neonatal age.
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