Acute EPA-induced learning and memory impairment in mice is prevented by DHA.
Acute EPA-induced learning and memory impairment in mice is prevented by DHA.
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DHA 可预防 EPA 引起的小鼠急性学习和记忆障碍。
DOI：
10.1038/s41467-020-19255-1
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发表时间：
2020-10-29
影响因子：
16.6
通讯作者：
Gao TM
中科院分区：
文献类型：
--
作者：
Liu JH;Wang Q;You QL;Li ZL;Hu NY;Wang Y;Jin ZL;Li SJ;Li XW;Yang JM;Zhu XH;Dai YF;Xu JP;Bai XC;Gao TM
二十碳五烯酸（EPA）是一种ω-3脂肪酸，已被广泛用于预防心血管疾病（CVD）和治疗脑疾病，单独或与二十二碳六烯酸（DHA）联合使用。然而，补充EPA和DHA对正常认知功能的影响以及EPA和DHA的分子靶点仍然未知。我们发现，急性管理局EPA损害学习和记忆和海马LTP在成年和青春期前的小鼠。通过内源性升高转基因fat-1小鼠海马中的EPA复制类似的缺陷。此外，EPA的损伤作用是通过增强经由5-HT 6 R的GABA能传递来介导的。有趣的是，DHA可以通过5-HT 2CR预防EPA诱导的损伤，EPA与DHA的比例与海洋鱼油相似。我们得出结论，EPA对认知功能表现出意想不到的有害影响，这表明在补充omega-3脂肪酸时必须谨慎，EPA和DHA以自然比例组合对学习和记忆以及突触可塑性至关重要。EPA急性给药损害小鼠的学习记忆和海马LTP，这是通过增强5-HT 6 R介导的GABA能传递介导的。DHA可以通过5-HT 2CR预防EPA诱导的损伤，其EPA与DHA的比例与海洋鱼油中的比例相似。
Eicosapentaenoic acid (EPA), an omega-3 fatty acid, has been widely used to prevent cardiovascular disease (CVD) and treat brain diseases alone or in combination with docosahexaenoic acid (DHA). However, the impact of EPA and DHA supplementation on normal cognitive function and the molecular targets of EPA and DHA are still unknown. We show that acute administration of EPA impairs learning and memory and hippocampal LTP in adult and prepubescent mice. Similar deficits are duplicated by endogenously elevating EPA in the hippocampus in the transgenic fat-1 mouse. Furthermore, the damaging effects of EPA are mediated through enhancing GABAergic transmission via the 5-HT6R. Interestingly, DHA can prevent EPA-induced impairments at a ratio of EPA to DHA similar to that in marine fish oil via the 5-HT2CR. We conclude that EPA exhibits an unexpected detrimental impact on cognitive functions, suggesting that caution must be exercised in omega-3 fatty acid supplementation and the combination of EPA and DHA at a natural ratio is critical for learning and memory and synaptic plasticity. Acute administration of EPA impairs learning and memory and hippocampal LTP in mice that was mediated through enhancing GABAergic transmission via the 5-HT6R. DHA can prevent EPA-induced impairments at a ratio of EPA to DHA similar to that in marine fish oil via the 5-HT2CR.
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影响因子：
4.8
作者：
Evans, Maggie C.;Rizwan, Mohammed Z.;Anderson, Greg M.
通讯作者：
Anderson, Greg M.
营养中的Docosahexaenoic酸信号脂肪组学：衰老，神经炎症，黄斑变性，阿尔茨海默氏症和其他神经退行性疾病的重要性。
影响因子：
8.9
作者：
Bazan NG;Molina MF;Gordon WC
通讯作者：
Gordon WC
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影响因子：
82.9
作者：
Cao, Xiong;Li, Liang-Ping;Gao, Tian-Ming
通讯作者：
Gao, Tian-Ming
影响因子：
4.7
作者：
Foley, Andrew G.;Hirst, Warren D.;Regan, Ciaran M.
通讯作者：
Regan, Ciaran M.
影响因子：
7.6
作者：
Delpech, Jean-Christophe;Madore, Charlotte;Laye, Sophie
通讯作者：
Laye, Sophie