The temporal onset of the core features in dementia with Lewy bodies.
The temporal onset of the core features in dementia with Lewy bodies.
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DOI：
10.1002/alz.12411
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Ferman TJ
中科院分区：
文献类型：
--
作者：
Choudhury P;Graff-Radford J;Aakre JA;Wurtz L;Knopman DS;Graff-Radford NR;Kantarci K;Forsberg LK;Fields JA;Pedraza O;Chen Q;Miyagawa T;Day GS;Tipton P;Savica R;Botha H;Lachner C;Dredla B;Reichard RR;Petersen RC;Dickson DW;Boeve BF;Ferman TJ
我们检查了可能的路易体痴呆（DLB）的核心特征的时间序列。在488例可能患有DLB的患者中，确定了男性和女性每个核心特征的发病时间和诊断时间，并确定了病理亚组（n = 209）。快速眼动睡眠行为障碍（RBD）先于其他核心特征在男性和女性中发展。男性患RBD的可能性更大，并且比女性更早被诊断出可能患有DLB。在男性中，视幻觉是在其他核心特征出现之后才出现的，但在女性中，视幻觉出现得更早，而且与波动和帕金森症同时出现。女性在第一次就诊时年龄较大，认知障碍更严重，患RBD的可能性更小，比男性更晚被诊断为可能的DLB，更容易出现新皮质缠结。男性、RBD和无新皮层缠结的路易体病较早出现可能的DLB。
We examined the temporal sequence of the core features in probable dementia with Lewy bodies (DLB). In 488 patients with probable DLB, the onset of each core feature and time to diagnosis was determined for men and women, and a pathologic subgroup (n = 209). REM sleep behavior disorder (RBD) developed before the other core features in men and women. Men were more likely to have RBD and were diagnosed with probable DLB earlier than women. Visual hallucinations developed after the other core features in men, but in women, they appeared earlier and concurrently with fluctuations and parkinsonism. Women were older and more cognitively impaired at first visit, were less likely to have RBD, more likely to be diagnosed with probable DLB later than men, and more likely to have neocortical tangles. An earlier latency to probable DLB was associated with men, RBD, and Lewy body disease without neocortical tangles.
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影响因子：
4.1
作者：
Dickson DW
通讯作者：
Dickson DW
影响因子：
4.8
作者：
Boeve, B. F.;Silber, M. H.;Ferman, T. J.;Lin, S. C.;Benarroch, E. E.;Schmeichel, A. M.;Ahlskog, J. E.;Caselli, R. J.;Jacobson, S.;Sabbagh, M.;Adler, C.;Woodruff, B.;Beach, T. G.;Iranzo, A.;Gelpi, E.;Santamaria, J.;Tolosa, E.;Singer, C.;Mash, D. C.;Luca, C.;Arnulf, I.;Duyckaerts, C.;Schenck, C. H.;Mahowald, M. W.;Dauvilliers, Y.;Graff-Radford, N. R.;Wszolek, Z. K.;Parisi, J. E.;Dugger, B.;Murray, M. E.;Dickson, D. W.
通讯作者：
Dickson, D. W.
影响因子：
4.3
作者：
Bugalho, Paulo;Salavisa, Manuel
通讯作者：
Salavisa, Manuel
影响因子：
6.9
作者：
Donaghy, Paul C.;Taylor, John-Paul;Thomas, Alan J.
通讯作者：
Thomas, Alan J.
影响因子：
4
作者：
Chiu, Pai-Yi;Teng, Po-Ren;Tsai, Chun-Tang
通讯作者：
Tsai, Chun-Tang