Who's Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling.

Who's Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling.
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DOI:
10.3390/v10090447
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发表时间:
2018-08-21
期刊:
Viruses
影响因子:
--
通讯作者:
Munger J
Munger J
中科院分区:
其他
文献类型:
--
作者:
Goodwin CM;Ciesla JH;Munger J

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作为宿主先天免疫应答的重要组成部分,NFκB和干扰素信号是感染结果的关键决定因素。在过去的25年里,许多人类巨细胞病毒(HCMV)基因已被鉴定为拮抗或调节这些途径的信号传导。在这里,我们回顾了改变NFκB和干扰素信号的HCMV因子的生物学,包括目前已知的这些病毒基因如何促进感染和持久性,以及仍然存在的主要悬而未决的问题。
As essential components of the host’s innate immune response, NFκB and interferon signaling are critical determinants of the outcome of infection. Over the past 25 years, numerous Human Cytomegalovirus (HCMV) genes have been identified that antagonize or modulate the signaling of these pathways. Here we review the biology of the HCMV factors that alter NFκB and interferon signaling, including what is currently known about how these viral genes contribute to infection and persistence, as well as the major outstanding questions that remain.
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