Who's Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling.
Who's Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling.
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DOI:
10.3390/v10090447
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发表时间:
2018-08-21
期刊:
影响因子:
--
通讯作者:
Munger J
中科院分区:
文献类型:
--
作者:
Goodwin CM;Ciesla JH;Munger J
As essential components of the host’s innate immune response, NFκB and interferon signaling are critical determinants of the outcome of infection. Over the past 25 years, numerous Human Cytomegalovirus (HCMV) genes have been identified that antagonize or modulate the signaling of these pathways. Here we review the biology of the HCMV factors that alter NFκB and interferon signaling, including what is currently known about how these viral genes contribute to infection and persistence, as well as the major outstanding questions that remain.
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