Sauti ya Vijana (SYV; The Voice of Youth): Longitudinal Outcomes of an Individually Randomized Group Treatment Pilot Trial for Young People Living with HIV in Tanzania.
Sauti ya Vijana (SYV; The Voice of Youth): Longitudinal Outcomes of an Individually Randomized Group Treatment Pilot Trial for Young People Living with HIV in Tanzania.
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DOI：
10.1007/s10461-021-03550-z
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发表时间：
2022-06
影响因子：
4.4
通讯作者：
Mmbaga BT
中科院分区：
文献类型：
--
作者：
Dow DE;O'Donnell KE;Mkumba L;Gallis JA;Turner EL;Boshe J;Shayo AM;Cunningham CK;Mmbaga BT
Sauti ya Vijana是由青年团体领导人提供的心理健康和生活技能干预措施，旨在改善坦桑尼亚艾滋病毒感染者的艾滋病毒结果。这项初步随机对照试验评估了与标准治疗相比的探索性干预有效性。YPLWH（N = 105）随机接受干预或SOC。参与者的平均年龄为18.1岁，53%为女性。30个月随访期间，两个研究组的心理健康指标（患者健康问卷[PHQ-9]、优势和困难问卷[SDQ]、UCLA创伤）平均评分均为无症状至轻度，波动不显著，为1-2分。在所有时间点，干预组的平均自我报告依从性均较高（但除6个月外，所有时间点的置信区间均为零）。与SOC相比，干预组中病毒学抑制（HIV RNA < 400拷贝/mL）的风险比在6个月时为1.15 [95% CI = 0.95，1.39]），在12个月时为1.17 [95% CI：0.92，1.48]，在18个月时为0.99 [95% CI：0.76，1.31]。虽然这些发现没有统计学意义，但HIV结局的趋势表明，SYV有望改善YPLWH的抗逆转录病毒治疗（ART）依从性和病毒学抑制。在线版本包含补充材料，可通过10.1007/s10461-021-03550-z获得。
Sauti ya Vijana is a mental health and life skills intervention delivered by young adult group leaders for the improvement of HIV outcomes in young people living with HIV in Tanzania. This pilot randomized controlled trial estimated exploratory intervention effectiveness compared to standard of care. YPLWH (N = 105) were randomized to receive intervention or SOC. The mean age of participants was 18.1 years and 53% were female. Mean scores on mental health measures (Patient Health Questionnaire [PHQ-9], Strengths and Difficulties Questionnaire [SDQ], UCLA Trauma) were asymptomatic to mild in both study arms through 30-month follow-up with a non-significant fluctuation of 1–2 points. The mean self-reported adherence was higher in the intervention arm across all time points (but the confidence interval contained the null at all time points except 6 months). Risk ratio of virologic suppression (HIV RNA < 400 copies/mL) in the intervention arm compared to SOC was 1.15 [95% CI = 0.95, 1.39]) at 6-months, 1.17 [95% CI: 0.92, 1.48] at 12-months, and 0.99 [95% CI 0.76, 1.31] at 18-months. Though these findings were not powered for statistical significance, the trends in HIV outcomes suggest that SYV holds promise for improving antiretroviral therapy (ART) adherence and virologic suppression in YPLWH. The online version contains supplementary material available at 10.1007/s10461-021-03550-z.
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