Resident colonic Escherichia coli strains frequently display uropathogenic characteristics.
Resident colonic Escherichia coli strains frequently display uropathogenic characteristics.
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结肠中常驻的大肠杆菌菌株经常表现出泌尿道致病特征。
DOI：
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发表时间：
1992
影响因子：
6.4
通讯作者：
C. Svanborg
中科院分区：
文献类型：
--
作者：
A. Wold;D. Caugant;G. Lidin‐Janson;P. Man;C. Svanborg
与结肠中长期存在相关的细菌因素尚未确定。通过染色体编码酶的电泳分型，对13例无症状菌尿女学生的结肠植物群中的个别大肠杆菌菌株进行了鉴定，并将其定义为常驻或短暂的。菌株的特点是血清型，受体特异性，并坚持人结肠上皮细胞系HT-29。结肠常驻菌株表达P菌毛，通过甘露糖耐药机制粘附于结肠上皮细胞，并表达尿路致病性血清型O 1，O2，O 6，O 7，O 18，O25或O 75更经常比瞬时菌株，这往往是不可分型。血清型和血凝模式一般保留在肠道运输，相反，这些属性的损失后，长期殖民的泌尿道。事实上，具有Gal α 1-4Gal β特异性粘附的P菌毛可能已经进化为增加结肠中的持久性。
Bacterial factors associated with long-term persistence in the colon have not been defined. Individual Escherichia coli strains in the colonic flora of 13 schoolgirls with asymptomatic bacteriuria were identified by electromorphic typing of chromosomally encoded enzymes and defined as resident or transient. The strains were characterized as to serotype, receptor specificity, and adherence to the human colonic epithelial cell line HT-29. Colonic resident strains expressed P fimbriae, adhered to colonic epithelial cells via a mannose-resistant mechanism, and expressed the uropathogenic serotypes O1, O2, O6, O7, O18, O25, or O75 more often than did the transient strains, which were often nontypeable. The serotype and hemagglutination pattern were generally retained during intestinal carriage, in contrast to the loss of such properties upon prolonged colonization of the urinary tract. P fimbriae with Gal alpha 1----4Gal beta-specific adherence may, in fact, have evolved to increase persistence in the colon.
由于细胞分泌产物的扩散受到限制，大肠杆菌粘附在组织培养细胞上的生长优势和增强的毒性。
DOI：
10.1172/jci112939
发表时间：
1987
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Zafriri,D;Oron,Y;Eisenstein,BI;Ofek,I
通讯作者：
Ofek,I