Association of vitamin D receptor gene polymorphism and Parkinson's disease in Koreans.
Association of vitamin D receptor gene polymorphism and Parkinson's disease in Koreans.
复制标题
DOI：
10.3346/jkms.2005.20.3.495
复制
发表时间：
2005-06
影响因子：
4.5
通讯作者：
Lee KS
中科院分区：
文献类型：
--
作者：
Kim JS;Kim YI;Song C;Yoon I;Park JW;Choi YB;Kim HT;Lee KS
1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), which is the biologically active form of vitamin D, has anti-inflammatory effects and can prevent experimental Parkinson's disease (PD). 1,25(OH)2D3 exerts most of its actions only after it binds to its specific nuclear receptors. Eighty-five Korean patients with PD and 231 unrelated healthy individuals were evaluated to determine if vitamin D receptor gene (VDRG) BsmI polymorphisms were markers for the susceptibility to PD in Korean patients. Each polymorphism was detected using polymerase chain reaction (PCR)-based restriction analysis. In addition, the relationship between the BsmI polymorphisms and the clinical manifestations of PD was evaluated. Overexpression of the b allele (91.2 vs. 85.7%; p=0.069) and homozygote bb (84.7 vs. 72.7%; p=0.043) was found in the PD patients compared with the controls. These results show for the first time an association between PD and a VDRG polymorphism, which might be involved in the pathogenesis of PD, or in the linkage disequilibrium of the VDRG to another pathogenic gene locus.
登录
查看更多内容
影响因子：
9.9
作者：
JANKOVIC, J;MCDERMOTT, M;WEINER, W
通讯作者：
WEINER, W
影响因子：
9.9
作者：
SCHOENBERG, BS;ANDERSON, DW;HAERER, AF
通讯作者：
HAERER, AF
影响因子：
9.9
作者：
ZETUSKY, WJ;JANKOVIC, J;PIROZZOLO, FJ
通讯作者：
PIROZZOLO, FJ
DOI：
10.1073/pnas.89.15.6665
发表时间：
1992-08-01
影响因子：
11.1
作者：
MORRISON, NA;YEOMAN, R;EISMAN, JA
通讯作者：
EISMAN, JA
影响因子：
2.9
作者：
Wang, JY;Wu, JN;Wang, Y
通讯作者：
Wang, Y