Associations of Arterial Stiffness and Carotid Atherosclerosis with Cerebral Small Vessel Disease in a Rural Community-Based Population.
Associations of Arterial Stiffness and Carotid Atherosclerosis with Cerebral Small Vessel Disease in a Rural Community-Based Population.
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DOI：
10.5551/jat.52530
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发表时间：
2020-09-01
影响因子：
4.4
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Zhang K;Jiang Y;Wang Y;Suo C;Xu K;Zhu Z;Zhu C;Zhao G;Jin L;Ye W;Cui M;Chen X
目的：我们的目的是检查四个颅外动脉指标与脑小血管疾病（CSVD）及其总负荷的相关性。方法：904名55-65岁的个体来自台州市影像学研究。根据脑磁共振成像对CSVD标志物，包括腔隙（LAC）、白色高信号（WMH）、脑微出血（CMB）和血管周围间隙（PVS）进行评级。我们还测量了颅外动脉指数，包括臂踝脉搏波速度（baPWV），踝臂指数，颈动脉内膜中层厚度（IMT）和颈动脉斑块。采用线性和二元Logistic回归分析这四个动脉指标与CSVD标志物之间的相关性。此外，还进行了有序和多项式逻辑回归，以评估动脉指标与CSVD总评分（范围为0-4分）之间的关系。结果如下：共有443名（49.0%）参与者被发现至少有一种CSVD标志物，包括172名（19.0%）WMH，184名（20.4%）LAC，147名（16.3%）CMB和226名（25.0%）PVS。baPWV增加与每种CSVD标志物显著相关，颈动脉IMT增加与LAC和PVS相关，颈动脉斑块的存在与WMH体积和PVS相关。此外，baPWV的每SD增量（比值比[OR]：1.29，95%置信区间[CI]：1.11-1.50）和颈动脉斑块的存在（OR：1.42，95% CI：1.05-1.92）与更高的总CSVD评分显著相关。结论：在中国农村地区，baPWV增加和颈动脉斑块的存在似乎与总CSVD负担相关。
Aims: We aimed to examine the associations of four extracranial artery indicators with cerebral small vessel disease (CSVD) and its total burden. Methods: A total of 904 individuals aged 55–65 years old were included from the Taizhou Imaging Study. CSVD markers, including lacunes (LAC), white matter hyperintensities (WMH), cerebral microbleeds (CMB), and perivascular spaces (PVS), were rated based on brain magnetic resonance imaging. We also measured extracranial artery indices, including the brachial-ankle pulse wave velocity (baPWV), the ankle-brachial index, the carotid intima-media thickness (IMT), and carotid plaque. Linear and binary logistic regressions were adopted to test the associations among these four artery indicators and each CSVD marker when appropriate. Additionally, ordinal and multinomial logistic regressions were performed to assess the relationships between artery indicators and total CSVD score (range from 0–4 points). Results: A total of 443 (49.0%) participants were found to have at least one of the CSVD markers, including 172 (19.0%) with WMH, 184 (20.4%) with LAC, 147 (16.3%) with CMB, and 226 (25.0%) with PVS. Increased baPWV was significantly associated with each CSVD marker, increasing carotid IMT was associated with LAC and PVS, and the presence of carotid plaque was associated with WMH volume and PVS. Moreover, per SD increment of baPWV (odds ratio [OR]: 1.29, 95% confidence interval [CI]: 1.11–1.50) and the presence of carotid plaque (OR: 1.42, 95% CI: 1.05–1.92) were significantly associated with greater total CSVD scores. Conclusion: Increased baPWV and the presence of carotid plaque appear to be associated with total CSVD burden in rural regions in China.
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影响因子：
5.3
作者：
Bouchi, Ryotaro;Babazono, Tetsuya;Uchigata, Yasuko
通讯作者：
Uchigata, Yasuko
影响因子：
9.9
作者：
Brisset, Marion;Boutouyrie, Pierre;Debette, Stephanie
通讯作者：
Debette, Stephanie
影响因子：
4.8
作者：
Huijts M;Duits A;van Oostenbrugge RJ;Kroon AA;de Leeuw PW;Staals J
通讯作者：
Staals J
影响因子：
1.9
作者：
CONOVER, WJ;IMAN, RL
通讯作者：
IMAN, RL
影响因子：
1.9
作者：
Jiang, Yanfeng;Fan, Zehan;Chen, Xingdong
通讯作者：
Chen, Xingdong